Membrane internalization mechanisms and design strategies of arginine-rich cell-penetrating peptides
Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …
acids, and macromolecules to permeate cell membranes, creating a novel route for …
Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …
Cell-penetrating dabcyl-containing tetraarginines with backbone aromatics as uptake enhancers
Cell-penetrating peptides represent an emerging class of carriers capable of effective
cellular delivery. This work demonstrates the preparation and investigation of efficient CPPs …
cellular delivery. This work demonstrates the preparation and investigation of efficient CPPs …
Influence of Aza-Glycine substitution on the internalization of penetratin
The cell-penetrating peptide (CPP) penetratin has gained much attention over many years
due to its potential role as a transporter for a broad range of cargo into cells. The …
due to its potential role as a transporter for a broad range of cargo into cells. The …
Enhancing cell penetration efficiency of cyclic oligoarginines using rigid scaffolds
Delivering therapeutic agents into cells has always been a major challenge. In recent years,
cyclization emerged as a tool for designing CPPs to increase their internalization and …
cyclization emerged as a tool for designing CPPs to increase their internalization and …
The balance between hydrophobicity/aromaticity and positively charged residues may influence the cell penetration ability
Cell-penetrating peptides (CPPs) are commonly modified to increase their cellular uptake,
alter the mechanism of penetration or enhance their endosomal release. Earlier, we …
alter the mechanism of penetration or enhance their endosomal release. Earlier, we …
A Quantitative Method to Distinguish Cytosolic from Endosome‐Trapped Cell‐Penetrating Peptides
Cell‐penetrating peptides are known to penetrate cells through endocytosis and
translocation. The two pathways are hardly distinguished in current cell assays. We …
translocation. The two pathways are hardly distinguished in current cell assays. We …
[PDF][PDF] Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System. Pharmaceutics 2022, 14, 907
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …