Membrane internalization mechanisms and design strategies of arginine-rich cell-penetrating peptides

M Hao, L Zhang, P Chen - International Journal of Molecular Sciences, 2022 - mdpi.com
Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - Pharmaceutics, 2022 - mdpi.com
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Cell-penetrating dabcyl-containing tetraarginines with backbone aromatics as uptake enhancers

M Yousef, I Szabó, J Murányi, F Illien, D Soltész, C Bató… - Pharmaceutics, 2022 - mdpi.com
Cell-penetrating peptides represent an emerging class of carriers capable of effective
cellular delivery. This work demonstrates the preparation and investigation of efficient CPPs …

Influence of Aza-Glycine substitution on the internalization of penetratin

K Tarchoun, D Soltész, V Farkas, HJ Lee, I Szabó… - Pharmaceutics, 2024 - mdpi.com
The cell-penetrating peptide (CPP) penetratin has gained much attention over many years
due to its potential role as a transporter for a broad range of cargo into cells. The …

Enhancing cell penetration efficiency of cyclic oligoarginines using rigid scaffolds

C Bató, I Szabó, Z Bánóczi - Pharmaceutics, 2023 - mdpi.com
Delivering therapeutic agents into cells has always been a major challenge. In recent years,
cyclization emerged as a tool for designing CPPs to increase their internalization and …

The balance between hydrophobicity/aromaticity and positively charged residues may influence the cell penetration ability

D Soltész, I Szabó, Z Bánóczi - Pharmaceutics, 2023 - mdpi.com
Cell-penetrating peptides (CPPs) are commonly modified to increase their cellular uptake,
alter the mechanism of penetration or enhance their endosomal release. Earlier, we …

A Quantitative Method to Distinguish Cytosolic from Endosome‐Trapped Cell‐Penetrating Peptides

F Illien, Z Bánóczi, S Sagan - ChemBioChem, 2024 - Wiley Online Library
Cell‐penetrating peptides are known to penetrate cells through endocytosis and
translocation. The two pathways are hardly distinguished in current cell assays. We …

[PDF][PDF] Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System. Pharmaceutics 2022, 14, 907

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - 2022 - academia.edu
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …