Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

Recent developments in nanoscience have appreciably modified how diseases are
prevented, diagnosed, and treated. Metal nanoparticles, specifically silver nanoparticles …

Microbial resistance to antibiotics is an ancient and dynamic issue that has brought a
situation reminiscent of the pre-antibiotic era to the limelight. Currently, antibiotic resistance …

Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

Phage therapy was implemented almost a century ago but was subsequently abandoned
when antibiotics emerged. However, the rapid emergence of drug-resistant, which has …

Antibiotic failure not only is due to the development of resistance by pathogens but can also
often be explained by persistence and tolerance. Persistence and tolerance can be included …

Colistin-resistant multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-
resistant (PDR) bacteria are highly lethal and many researchers have tried hard to combat …

Highlights•Endolysins are promising novel therapeutics for treatment of bacterial
infections.•Endolysins can target infections in different organs and tissues of the human …

Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …

Bacteriophage-encoded endolysins (lysins) have emerged as a novel class of antibacterial
agents to combat the surging antibiotic resistance. Lysins have specific structures and …