Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …

Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10
people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to …

Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …

The tumour microenvironment possesses mechanisms that suppress anti-tumour immunity.
Itaconate is a metabolite produced from the Krebs cycle intermediate cis-aconitate by the …

Summary Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and
activates type I interferon signaling and plays an essential role in antitumor immunity …

Emerging research has identified metabolic pathways that are crucial for the proper
regulation of immune cells and how, when deranged, they can cause immune dysfunction …

Nutrient availability is central for T-cell functions and immune responses. Here we report that
CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non …

Macrophages represent the first line of defence in innate immune responses and
additionally serve important functions for the regulation of host inflammation and tissue …

Recently, electrical stimulation, as a non-pharmacological physical stimulus, has been
widely exploited in biomedical and clinical applications due to its ability to significantly …