Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease
Y Yoshimatsu, T Watabe - Inflammation and Regeneration, 2022 - Springer
Abstract Endothelial–mesenchymal transition (EndoMT), a cellular differentiation process in
which endothelial cells (ECs) lose their properties and differentiate into mesenchymal cells …
which endothelial cells (ECs) lose their properties and differentiate into mesenchymal cells …
Regulation of ZEB1 function and molecular associations in tumor progression and metastasis
M Perez-Oquendo, DL Gibbons - Cancers, 2022 - mdpi.com
Simple Summary Given the importance of the epithelial-to-mesenchymal transition in tumor
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue
Disruption of pulmonary vascular homeostasis is a central feature of viral pneumonia,
wherein endothelial cell (EC) death and subsequent angiogenic responses are critical …
wherein endothelial cell (EC) death and subsequent angiogenic responses are critical …
EMT-inducing transcription factors, drivers of melanoma phenotype switching, and resistance to treatment
Y Tang, S Durand, S Dalle, J Caramel - Cancers, 2020 - mdpi.com
Transcription factors, extensively described for their role in epithelial–mesenchymal
transition (EMT-TFs) in epithelial cells, also display essential functions in the melanocyte …
transition (EMT-TFs) in epithelial cells, also display essential functions in the melanocyte …
[HTML][HTML] ZEB1 transcription factor promotes immune escape in melanoma
M Plaschka, V Benboubker, M Grimont… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background The efficacy of immunotherapies in metastatic melanoma depends on a robust
T cell infiltration. Oncogenic alterations of tumor cells have been associated to T cell …
T cell infiltration. Oncogenic alterations of tumor cells have been associated to T cell …
The role of the ZEB1–neuroinflammation axis in CNS disorders
E Poonaki, UD Kahlert, SG Meuth, A Gorji - Journal of Neuroinflammation, 2022 - Springer
Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–
mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of …
mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of …
Seamless genetic recording of transiently activated mesenchymal gene expression in endothelial cells during cardiac fibrosis
S Zhang, Y Li, X Huang, K Liu, QD Wang, AF Chen… - Circulation, 2021 - Am Heart Assoc
Background: Cardiac fibrosis is a lethal outcome of excessive formation of myofibroblasts
that are scar-forming cells accumulated after heart injury. It has been reported that cardiac …
that are scar-forming cells accumulated after heart injury. It has been reported that cardiac …
DLL1 orchestrates CD8+ T cells to induce long-term vascular normalization and tumor regression
N Zhang, R Yin, P Zhou, X Liu, P Fan… - Proceedings of the …, 2021 - National Acad Sciences
The immunosuppressive and hypoxic tumor microenvironment (TME) remains a major
obstacle to impede cancer immunotherapy. Here, we showed that elevated levels of Delta …
obstacle to impede cancer immunotherapy. Here, we showed that elevated levels of Delta …
Enhancement of tumour penetration by nanomedicines through strategies based on transport processes and barriers
H Yang, Z Tong, S Sun, Z Mao - Journal of Controlled Release, 2020 - Elsevier
Nanomedicines for antitumour therapy have been widely studied in recent decades, but only
a few have been used in clinical applications. One of the most important reasons is the poor …
a few have been used in clinical applications. One of the most important reasons is the poor …
Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454–3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint …
Y Xia, WC Wang, WH Shen, K Xu, YY Hu… - Chemico-Biological …, 2021 - Elsevier
Background Non-small cell lung cancer (NSCLC) accounts for about 80–85% of total lung
cancer cases. Identifying the molecular mechanisms of anti-tumor drugs is essential for …
cancer cases. Identifying the molecular mechanisms of anti-tumor drugs is essential for …