Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

S Wang, X Su, M Xu, X Xiao, X Li, H Li… - Stem cell research & …, 2019 - Springer
Objective Although adipocytes are the most abundant stromal cell component in breast
cancer tissues, their interaction with breast cancer cells has been less investigated …

Mammary gland adipocytes in lactation cycle, obesity and breast cancer

G Colleluori, J Perugini, G Barbatelli, S Cinti - Reviews in Endocrine and …, 2021 - Springer
The mammary gland (MG) is an exocrine gland present in female mammals responsible for
the production and secretion of milk during the process of lactation. It is mainly composed by …

Exercise training in cancer control and treatment

JF Christensen, C Simonsen… - Comprehensive …, 2011 - Wiley Online Library
Exercise training is playing an increasing role in cancer care, as accumulating evidence
demonstrates that exercise may prevent cancer, control disease progression, interact with …

[HTML][HTML] Myeloid Slc2a1-deficient murine model revealed macrophage activation and metabolic phenotype are fueled by GLUT1

AJ Freemerman, L Zhao, AK Pingili, B Teng… - The Journal of …, 2019 - journals.aai.org
Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly
affecting immune activation. A classic response to proinflammatory activation is increased …

Bioprinting and differentiation of adipose-derived stromal cell spheroids for a 3D breast cancer-adipose tissue model

H Horder, M Guaza Lasheras, N Grummel… - Cells, 2021 - mdpi.com
Biofabrication, including printing technologies, has emerged as a powerful approach to the
design of disease models, such as in cancer research. In breast cancer, adipose tissue has …

[HTML][HTML] Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

TI Maulana, E Kromidas, L Wallstabe… - Advanced Drug Delivery …, 2021 - Elsevier
The advances in cancer immunotherapy come with several obstacles, limiting its
widespread use and benefits so far only to a small subset of patients. One of the underlying …

Cancer stem cells and the tumor microenvironment: targeting the critical crosstalk through nanocarrier systems

A Nayak, NM Warrier, P Kumar - Stem cell reviews and reports, 2022 - Springer
The physiological state of the tumor microenvironment (TME) plays a central role in cancer
development due to multiple universal features that transcend heterogeneity and niche …

Obesity, sleep apnea, and cancer

I Almendros, MA Martinez-Garcia, R Farré… - International Journal of …, 2020 - nature.com
The interest on a potential association between cancer and sleep-disordered breathing
(SDB) has clearly gained substantial traction over the last several years. This novel …

Obesity and cancer metastasis: molecular and translational perspectives

S Annett, G Moore, T Robson - Cancers, 2020 - mdpi.com
Simple Summary A major challenge in treating cancer is when the cancer spreads from its
original site to other parts of the body, a process also known as metastasis. In order to …

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

X Yin, Y Chen, R Ruze, R Xu, J Song… - Signal Transduction and …, 2022 - nature.com
The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …