Obesity is an established risk factor for many cancers and has recently been found to alter
the efficacy of T cell–based immunotherapies. Currently, however, the effects of obesity on …

Obesity is associated with increased risk and reduced survival for many types of cancer.
Increasing adiposity may affect the balance between immunosuppressive and antitumor …

Exosomes are membrane-bound extracellular vesicles (EVs) that transport bioactive
materials between cells and organs. The cargo delivered by exosomes can alter a wide …

There is increasing evidence suggesting the role of microbiome alterations in relation to
pancreatic adenocarcinoma and tumor immune functionality. However, molecular …

Berberine (BBR) exerts specific therapeutic effects on various diseases such as diabetes,
obesity, and other inflammation-associated diseases. However, the low oral bioavailability …

Obesity is a modern pandemic with negative consequences in women's reproductive health.
Women with overweight and obesity can develop mammary gland alterations that unable …

Cancer-associated adipocytes have functional roles in tumor development through secreted
adipocyte-derived factors and exosomes and also through metabolic symbiosis, where the …

Purpose: Breast cancer (BC) is globally the main reason of cancer-related deaths in women.
Omentin-1, an anti-inflammatory and antioxidant adipokine, plays different roles in …

The co-stimulatory CD40-CD40L dyad plays an important role in chronic inflammatory
diseases associated with aging. Although CD40 is mainly expressed by immune cells, CD40 …

Overweight and obesity, as a result of excess fat accumulation, have become a worldwide
public health issue. Recent studies have shown that obesity is closely related to many …