[HTML][HTML] Signaling within the epithelial ovarian cancer tumor microenvironment: the challenge of tumor heterogeneity

M Horowitz, E Esakov, P Rose… - Annals of Translational …, 2020 - ncbi.nlm.nih.gov
Epithelial ovarian cancer (EOC) is a leading cause of cancer death in women. Standard of
care treatment has remained platinum-containing cytotoxic chemotherapy for over three …

Type I interferons as joint regulators of tumor growth and obesity

S Gessani, F Belardelli - Cancers, 2021 - mdpi.com
Simple Summary The escalating global epidemic of overweight and obesity is a major public
health and economic problem, as excess body weight represents a significant risk factor for …

Cohesive cancer invasion of the biophysical barrier of smooth muscle

WL Harryman, KD Marr, D Hernandez-Cortes… - Cancer and Metastasis …, 2021 - Springer
Smooth muscle is found around organs in the digestive, respiratory, and reproductive tracts.
Cancers arising in the bladder, prostate, stomach, colon, and other sites progress from low …

Periostin drives extracellular matrix degradation, stemness, and chemoresistance by activating the MAPK/ERK signaling pathway in triple–negative breast cancer cells

J Wu, J Li, H Xu, N Qiu, X Huang, H Li - Lipids in Health and Disease, 2023 - Springer
Background Adipose tissue, which is mainly composed of adipocytes, is a crucial
component of the tumor microenvironment, particularly in breast cancer. Adipocytes …

Automatic segmentation of CT images for ventral body composition analysis

Y Fu, JE Ippolito, DR Ludwig, R Nizamuddin… - Medical …, 2020 - Wiley Online Library
Purpose Body composition is known to be associated with many diseases including
diabetes, cancers, and cardiovascular diseases. In this paper, we developed a fully …

Prognostic and predictive impact of beta-2 adrenergic receptor expression in HER2-positive breast cancer

R Caparica, F Richard, M Brandão, A Awada… - Clinical breast …, 2020 - Elsevier
Background Beta-2 adrenergic receptor (ADRB2) mediates proliferation and treatment
resistance in preclinical models of human epidermal growth factor receptor 2 positive …

Endurance exercise mitigates immunometabolic adipose tissue disturbances in cancer and obesity

JC Rosa-Neto, LS Silveira - International journal of molecular sciences, 2020 - mdpi.com
Adipose tissue is considered an endocrine organ whose complex biology can be explained
by the diversity of cell types that compose this tissue. The immune cells found in the stromal …

Obesity alters the ovarian DNA damage response and apoptotic proteins

KL Clark, CM Roach, AF Keating - Reproduction, 2020 - rep.bioscientifica.com
In the overweight or obese female, reproductive complications include poor oocyte quality,
decreased fecundity, gestational diabetes, and higher risk of reproductive cancers. Using …

[HTML][HTML] Promoting accuracy in low-magnification histopathology grading: With augmentation and multi-dilation model

Z Gan, A Subasi - Biomedical Signal Processing and Control, 2023 - Elsevier
Advances in artificial intelligence have facilitated the automated grading of histopathology
slides. Yet, the magnification of whole slide scanners (WSS) has restrained the accuracy of …

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

KM Hamel, TP Frazier, C Williams, T Duplessis… - International Journal of …, 2024 - mdpi.com
Female breast cancer accounts for 15.2% of all new cancer cases in the United States, with
a continuing increase in incidence despite efforts to discover new targeted therapies. With …