Cryptococcal meningitis diagnostics and screening in the era of point-of-care laboratory testing
R Rajasingham, RM Wake, T Beyene… - Journal of clinical …, 2019 - Am Soc Microbiol
Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected
persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg) …
persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg) …
Cryptococcal meningitis: diagnosis and management update
Recent advances in the diagnosis and management of cryptococcal meningitis are
promising and have been improving long-term survival. Point of care testing has made …
promising and have been improving long-term survival. Point of care testing has made …
The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis
R Rajasingham, NP Govender, A Jordan… - The Lancet infectious …, 2022 - thelancet.com
Background Cryptococcal meningitis is the most common cause of meningitis in adults living
with HIV in sub-Saharan Africa. The estimates of national, regional, and global burden of …
with HIV in sub-Saharan Africa. The estimates of national, regional, and global burden of …
Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial
Background Identifying new antifungals for cryptococcal meningitis is a priority given the
inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity …
inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity …
Cryptococcal meningitis
Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …
Cryptococcal meningoencephalitis: time for action
Cryptococcal meningoencephalitis was first described over a century ago. This fungal
infection is preventable and treatable yet continues to be associated with excessive …
infection is preventable and treatable yet continues to be associated with excessive …
Fungal CNS infections in Africa: the neuroimmunology of cryptococcal meningitis
SH Mohamed, TK Nyazika, K Ssebambulidde… - Frontiers in …, 2022 - frontiersin.org
Cryptococcal meningitis (CM) is the leading cause of central nervous system (CNS) fungal
infections in humans, with the majority of cases reported from the African continent. This is …
infections in humans, with the majority of cases reported from the African continent. This is …
Cryptococcal Disease in Diverse Hosts
DB Meya, PR Williamson - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points Cryptococcal Disease in Diverse Hosts Worldwide, cryptococcal meningitis kills
up to 180,000 persons annually and is the most common cause of nonviral meningitis in the …
up to 180,000 persons annually and is the most common cause of nonviral meningitis in the …
The changing epidemiology of HIV-associated adult meningitis, Uganda 2015–2017
J Ellis, AS Bangdiwala, FV Cresswell… - Open forum …, 2019 - academic.oup.com
Background Central nervous system (CNS) infections remain a major public health problem
in Sub-Saharan Africa, causing 15%–25% of AIDS-related deaths. With widespread …
in Sub-Saharan Africa, causing 15%–25% of AIDS-related deaths. With widespread …
Advanced HIV disease: A review of diagnostic and prophylactic strategies
A Lehman, J Ellis, E Nalintya, NC Bahr, A Loyse… - HIV …, 2023 - Wiley Online Library
Background Despite expanded access to antiretroviral therapy (ART) and the rollout of the
World Health Organization's (WHO)'test‐and‐treat'strategy, the proportion of people with HIV …
World Health Organization's (WHO)'test‐and‐treat'strategy, the proportion of people with HIV …