Subdivisions of the prefrontal cortex (PFC) evolved at different times. Agranular parts of the
PFC emerged in early mammals, and rodents, primates, and other modern mammals share …

Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …

This paper outlines a hierarchical Bayesian framework for interoception,
homeostatic/allostatic control, and meta-cognition that connects fatigue and depression to …

To understand what makes sleep vulnerable in disease, it is useful to look at how wake-
promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited …

For over three decades, Allan N. Schore has authored numerous volumes, chapters, and
articles on regulation theory, a biopsychosocial model of the development …

The authors present a unified account of 2 neural systems concerned with the development
and expression of adaptive behaviors: a mesencephalic dopamine system for reinforcement …

None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …

Cognition and comportment are subserved by interconnected neural networks that allow
high‐level computational architectures including parallel distributed processing. Cognitive …

To better understand the molecular and cellular differences in brain organization between
human and nonhuman primates, we performed transcriptome sequencing of 16 regions of …