Intensive care unit (ICU) patients with end-organ failure will require specialised machines or
extracorporeal therapies to support the failing organs that would otherwise lead to death …

Objective: Extracorporeal membrane oxygenation (ECMO) utilization is increasing on a
global scale, and despite technological advances, minimal standardized approaches to …

Introduction Antibiotics are commonly prescribed in critical care, and given the large
variability of pharmacokinetic (PK) parameters in these patients, drug PK frequently varies …

This study determined the pharmacokinetics of cefepime in patients requiring extracorporeal
membrane oxygenation (ECMO) support to guide dosage selection. Cefepime population …

Sepsis and septic shock remain the leading causes of death in intensive care units. Some
patients with sepsis fail to respond to routine treatment and rapidly progress to refractory …

Extracorporeal membrane oxygenation (ECMO) is a complex therapy aimed at providing
mechanical support for patients with severe, life‐threating cardiac and/or respiratory failure …

Background Extracorporeal membrane oxygenation (ECMO) is a life-saving modality but
has the potential to alter the pharmacokinetics (PK) of antimicrobials. Imipenem/cilastatin …

Effective treatment of sepsis not only demands prompt administration of appropriate
antimicrobials but also requires precise dosing to enhance the likelihood of patient survival …

Optimal antibiotic therapy for critically ill patients can be complicated by the altered
physiology associated with critical illness. Antibiotic pharmacokinetics and exposures can …

Optimal antibiotic therapy for critically ill patients can be complicated by the altered
physiology associated with critical illness. Antibiotic pharmacokinetics and exposures can …