Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS
TE Faust, G Gunner, DP Schafer - Nature Reviews Neuroscience, 2021 - nature.com
Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …
[HTML][HTML] Conscious processing and the global neuronal workspace hypothesis
We review the central tenets and neuroanatomical basis of the global neuronal workspace
(GNW) hypothesis, which attempts to account for the main scientific observations regarding …
(GNW) hypothesis, which attempts to account for the main scientific observations regarding …
Autism genes converge on asynchronous development of shared neuron classes
B Paulsen, S Velasco, AJ Kedaigle, M Pigoni… - Nature, 2022 - nature.com
Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes
spanning a wide range of biological functions,,,,–. The alterations in the human brain …
spanning a wide range of biological functions,,,,–. The alterations in the human brain …
Identification, evaluation, and management of children with autism spectrum disorder
SL Hyman, SE Levy, SM Myers, DZ Kuo, S Apkon… - …, 2020 - publications.aap.org
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with reported
prevalence in the United States of 1 in 59 children (approximately 1.7%). Core deficits are …
prevalence in the United States of 1 in 59 children (approximately 1.7%). Core deficits are …
[HTML][HTML] Neurodevelopmental disorders: from genetics to functional pathways
I Parenti, LG Rabaneda, H Schoen, G Novarino - Trends in Neurosciences, 2020 - cell.com
Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development
and function and are characterized by wide genetic and clinical variability. In this review, we …
and function and are characterized by wide genetic and clinical variability. In this review, we …
Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
VS Sohal, JLR Rubenstein - Molecular psychiatry, 2019 - nature.com
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
[HTML][HTML] SynGO: an evidence-based, expert-curated knowledge base for the synapse
F Koopmans, P van Nierop, M Andres-Alonso… - Neuron, 2019 - cell.com
Synapses are fundamental information-processing units of the brain, and synaptic
dysregulation is central to many brain disorders (" synaptopathies"). However, systematic …
dysregulation is central to many brain disorders (" synaptopathies"). However, systematic …
[HTML][HTML] Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
[HTML][HTML] Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental …
The complex pathophysiology of autism spectrum disorder encompasses interactions
between genetic and environmental factors. On the one hand, hundreds of genes …
between genetic and environmental factors. On the one hand, hundreds of genes …
Sensory perception in autism
CE Robertson, S Baron-Cohen - Nature Reviews Neuroscience, 2017 - nature.com
Autism is a complex neurodevelopmental condition, and little is known about its
neurobiology. Much of autism research has focused on the social, communication and …
neurobiology. Much of autism research has focused on the social, communication and …