[HTML][HTML] Interactions between tumor-derived proteins and Toll-like receptors

GY Jang, JW Lee, YS Kim, SE Lee, HD Han… - … & molecular medicine, 2020 - nature.com
Damage-associated molecular patterns (DAMPs) are danger signals (or alarmins) alerting
immune cells through pattern recognition receptors (PRRs) to begin defense activity …

Extracellular heat shock proteins: a new location, a new function

A De Maio, D Vazquez - Shock, 2013 - journals.lww.com
The expression of heat shock proteins (HSPs) is a basic and well-conserved cellular
response to an array of stresses. These proteins are involved in the repair of cellular …

[HTML][HTML] The dark-side of the outside: How extracellular heat shock proteins promote cancer

L Seclì, F Fusella, L Avalle, M Brancaccio - Cellular and Molecular Life …, 2021 - Springer
In addition to exerting several essential house-keeping activities in the cell, heat shock
proteins (HSPs) are crucial players in a well-structured molecular program activated in …

Hsp70 in cancer: A double agent in the battle between survival and death

MA Vostakolaei, L Hatami‐Baroogh… - Journal of cellular …, 2021 - Wiley Online Library
The heat shock protein (Hsps) superfamily, also known as molecular chaperones, are highly
conserved and present in all living organisms and play vital roles in protein fate. The …

Trial Watch: Toll-like receptor agonists for cancer therapy

E Vacchelli, A Eggermont, C Sautès-Fridman… - …, 2013 - Taylor & Francis
Toll-like receptors (TLRs) have long been known for their ability to initiate innate immune
responses upon exposure to conserved microbial components such as lipopolysaccharide …

[HTML][HTML] The role of extracellular HSP70 in the function of tumor-associated immune cells

M Linder, E Pogge von Strandmann - Cancers, 2021 - mdpi.com
Simple Summary The intracellular heat shock protein 70 (HSP70) is essential for cells to
respond to stress, for instance, by refolding damaged proteins or inhibiting apoptosis …

LncRNA HOTAIR enhances breast cancer radioresistance through facilitating HSPA1A expression via sequestering miR‐449b‐5p

S Zhang, B Wang, H Xiao, J Dong, Y Li, C Zhu… - Thoracic …, 2020 - Wiley Online Library
Background Breast cancer (BRCA) is the leading cause of cancer‐related death in women
worldwide. Pre‐and postoperative radiotherapy play a pivotal role in BRCA treatment but its …

[HTML][HTML] The expression profiles and prognostic values of HSP70s in hepatocellular carcinoma

B Wang, T Lan, H Xiao, ZH Chen, C Wei, LF Chen… - Cancer cell …, 2021 - Springer
Background The HSP70 family of heat shock protein plays a critical role in protein synthesis
and transport to maintain protein homeostasis. Several studies have indicated that HSP70s …

Extracellular Hsp70: export and function

A De Maio - Current Protein and Peptide Science, 2014 - ingentaconnect.com
The most conserved cellular response to stress is the expression of heat shock proteins
(hsp). These proteins participate in the repair of cellular damage after the stress, which is …

[HTML][HTML] The complex function of hsp70 in metastatic cancer

AM Lipp, B Nimmervoll, A Sonnleitner, J Hesse… - Cancers, 2014 - mdpi.com
Elevated expression of the inducible heat shock protein 70 (Hsp70) is known to correlate
with poor prognosis in many cancers. Hsp70 confers survival advantage as well as …