[HTML][HTML] Promises and challenges of adoptive T-cell therapies for solid tumours
Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
Cost of decentralized CAR T‐cell production in an academic nonprofit setting
Chimeric antigen receptor (CAR) T‐cell therapy is a promising immunotherapy with high
acquisition costs, and it has raised concerns about affordability and sustainability in many …
acquisition costs, and it has raised concerns about affordability and sustainability in many …
[HTML][HTML] Chimeric antigen receptor–T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods
RP Harrison, E Zylberberg, S Ellison, BL Levine - Cytotherapy, 2019 - Elsevier
Cell and gene therapies have demonstrated excellent clinical results across a range of
indications with chimeric antigen receptor (CAR)–T cell therapies among the first to reach …
indications with chimeric antigen receptor (CAR)–T cell therapies among the first to reach …
Distributed clustering using multi-tier hierarchical overlay super-peer peer-to-peer network architecture for efficient customer segmentation
YSK Manjunath, RF Kashef - Electronic Commerce Research and …, 2021 - Elsevier
Customer segmentation divides customers into groups of consumers with similar patterns or
characteristics relevant to marketing, especially with respect to target advertising. These …
characteristics relevant to marketing, especially with respect to target advertising. These …
[HTML][HTML] Re-envisioning pharmaceutical manufacturing: increasing agility for global patient access
M Algorri, MJ Abernathy, NS Cauchon… - Journal of …, 2022 - Elsevier
The traditional paradigm for pharmaceutical manufacturing is focused primarily upon
centralized facilities that enable mass production and distribution. While this system reliably …
centralized facilities that enable mass production and distribution. While this system reliably …
Comparison between centralized and decentralized supply chains of autologous chimeric antigen receptor T-cell therapies: a UK case study based on discrete event …
Background aims Decentralized, or distributed, manufacturing that takes place close to the
point of care has been a manufacturing paradigm of heightened interest within the cell …
point of care has been a manufacturing paradigm of heightened interest within the cell …
[HTML][HTML] How cellular agriculture systems can promote food security
E Soice, J Johnston - Frontiers in Sustainable Food Systems, 2021 - frontiersin.org
Cellular agriculture, the manufacturing of animal-sourced foods by cell cultures, may
promote food security by providing a food source that is available, accessible, utilized, and …
promote food security by providing a food source that is available, accessible, utilized, and …
A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies
Background aims Autologous cell therapy (AuCT) is an emerging therapeutic treatment that
is undergoing transformation from laboratory-to industry-scale manufacturing with recent …
is undergoing transformation from laboratory-to industry-scale manufacturing with recent …
[HTML][HTML] Cyberbiosecurity in advanced manufacturing models
D Guttieres, S Stewart, J Wolfrum… - … in bioengineering and …, 2019 - frontiersin.org
Cybersecurity for the production of safe and effective biopharmaceuticals requires the
attention of multiple stakeholders, including industry, governments, and healthcare …
attention of multiple stakeholders, including industry, governments, and healthcare …
Objectives, benefits and challenges of bioreactor systems for the clinical-scale expansion of T lymphocyte cells
T Baudequin, R Nyland, H Ye - Biotechnology Advances, 2021 - Elsevier
Cell therapies based on T cell have gathered interest over the last decades for treatment of
cancers, becoming recently the most investigated lineage for clinical trials. Although results …
cancers, becoming recently the most investigated lineage for clinical trials. Although results …