[HTML][HTML] Promises and challenges of adoptive T-cell therapies for solid tumours

M Morotti, A Albukhari, A Alsaadi, M Artibani… - British journal of …, 2021 - nature.com
Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …

Cost of decentralized CAR T‐cell production in an academic nonprofit setting

T Ran, SB Eichmüller, P Schmidt… - International journal of …, 2020 - Wiley Online Library
Chimeric antigen receptor (CAR) T‐cell therapy is a promising immunotherapy with high
acquisition costs, and it has raised concerns about affordability and sustainability in many …

[HTML][HTML] Chimeric antigen receptor–T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods

RP Harrison, E Zylberberg, S Ellison, BL Levine - Cytotherapy, 2019 - Elsevier
Cell and gene therapies have demonstrated excellent clinical results across a range of
indications with chimeric antigen receptor (CAR)–T cell therapies among the first to reach …

Distributed clustering using multi-tier hierarchical overlay super-peer peer-to-peer network architecture for efficient customer segmentation

YSK Manjunath, RF Kashef - Electronic Commerce Research and …, 2021 - Elsevier
Customer segmentation divides customers into groups of consumers with similar patterns or
characteristics relevant to marketing, especially with respect to target advertising. These …

[HTML][HTML] Re-envisioning pharmaceutical manufacturing: increasing agility for global patient access

M Algorri, MJ Abernathy, NS Cauchon… - Journal of …, 2022 - Elsevier
The traditional paradigm for pharmaceutical manufacturing is focused primarily upon
centralized facilities that enable mass production and distribution. While this system reliably …

Comparison between centralized and decentralized supply chains of autologous chimeric antigen receptor T-cell therapies: a UK case study based on discrete event …

C Lam, E Meinert, A Yang, Z Cui - Cytotherapy, 2021 - Elsevier
Background aims Decentralized, or distributed, manufacturing that takes place close to the
point of care has been a manufacturing paradigm of heightened interest within the cell …

[HTML][HTML] How cellular agriculture systems can promote food security

E Soice, J Johnston - Frontiers in Sustainable Food Systems, 2021 - frontiersin.org
Cellular agriculture, the manufacturing of animal-sourced foods by cell cultures, may
promote food security by providing a food source that is available, accessible, utilized, and …

A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies

K Wang, Y Liu, J Li, B Wang, R Bishop, C White, A Das… - Cytotherapy, 2019 - Elsevier
Background aims Autologous cell therapy (AuCT) is an emerging therapeutic treatment that
is undergoing transformation from laboratory-to industry-scale manufacturing with recent …

[HTML][HTML] Cyberbiosecurity in advanced manufacturing models

D Guttieres, S Stewart, J Wolfrum… - … in bioengineering and …, 2019 - frontiersin.org
Cybersecurity for the production of safe and effective biopharmaceuticals requires the
attention of multiple stakeholders, including industry, governments, and healthcare …

Objectives, benefits and challenges of bioreactor systems for the clinical-scale expansion of T lymphocyte cells

T Baudequin, R Nyland, H Ye - Biotechnology Advances, 2021 - Elsevier
Cell therapies based on T cell have gathered interest over the last decades for treatment of
cancers, becoming recently the most investigated lineage for clinical trials. Although results …