HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
T cell antigen discovery
AV Joglekar, G Li - Nature methods, 2021 - nature.com
T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …
recognize short peptide antigens presented on major histocompatibility complex (MHC) …
[HTML][HTML] Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells
DA Michelson, K Hase, T Kaisho, C Benoist, D Mathis - Cell, 2022 - cell.com
Medullary thymic epithelial cells (mTECs) ectopically express thousands of peripheral-tissue
antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T …
antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T …
CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19
V Mallajosyula, C Ganjavi, S Chakraborty… - Science …, 2021 - science.org
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …
[HTML][HTML] Shortwave-infrared-light-emitting probes for the in vivo tracking of cancer vaccines and the elicited immune responses
Tracking and imaging immune cells in vivo non-invasively would offer insights into the
immune responses induced by vaccination. Here we report a cancer vaccine consisting of …
immune responses induced by vaccination. Here we report a cancer vaccine consisting of …
[HTML][HTML] Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma
CC Smith, KE Beckermann, DS Bortone… - The Journal of …, 2019 - Am Soc Clin Investig
Human endogenous retroviruses (hERVs) are remnants of exogenous retroviruses that have
integrated into the genome throughout evolution. We developed a computational workflow …
integrated into the genome throughout evolution. We developed a computational workflow …
Association between expression level of PD1 by tumor-infiltrating CD8+ T cells and features of hepatocellular carcinoma
Background & Aims T-cell exhaustion, or an impaired capacity to secrete cytokines and
proliferate with overexpression of immune checkpoint receptors, occurs during chronic viral …
proliferate with overexpression of immune checkpoint receptors, occurs during chronic viral …
[HTML][HTML] Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope
We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein 269-277 epitope …
respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein 269-277 epitope …
T cell antigen discovery via trogocytosis
T cell receptor (TCR) ligand discovery is essential for understanding and manipulating
immune responses to tumors. We developed a cell-based selection platform for TCR ligand …
immune responses to tumors. We developed a cell-based selection platform for TCR ligand …