The local generation of phosphatidic acid plays a key role in the regulation of intracellular
membrane transport through mechanisms which are largely unknown. Phosphatidic acid …

Phospholipase D exists in various forms that differ in their regulation but predominantly
hydrolyze phosphatidylcholine. The Ca (2+)-dependent isozymes of protein kinase C …

To understand the mechanism of membrane fusion, we have to infer the sequence of
structural transformations that occurs during the process. Here, it is shown how one can …

It has long been recognized that the neutral forms of weak acids and weak bases can
permeate through lipid bilayer membranes at much faster rates than the charged forms …

During the 1980s, several cellular factors that enhanced cholera toxin-catalyzed ADP-
ribosylation of Gsa or activation of adenylyl cyclase were described. Kahn and Gilman (1) …

MATERIALS AND METHODS Lipids andChemicals. Egg phosphatidylcholine (EPC),
dioleoylphosphatidylethanolamine (DOPE), A-(7-nitro-2, 1, 3-benzoxadiazol-4-yl)-1, 2 …

Activation of human platelets by complement proteins, C5b-9, thrombin plus collagen, or a
Ca2+ ionophore results in surface exposure of phosphatidylserine (PS), accompanied by …

Membrane fusion is critical to biological processes such as viral infection, endocrine
hormone secretion, and neurotransmission, yet the precise mechanistic details of the fusion …

The roles of lipids expand beyond the basic building blocks of biological membranes. In
addition to forming complex and dynamic barriers, the thousands of different lipid species in …

The structural and thermotropic properties of alpha-hydroxy fatty acid (HFA) and non-
hydroxy fatty acid (NFA) ceramides (CER) have been studied using differential scanning …