Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …

Fibrosis represents the common end stage of chronic organ injury independent of the initial
insult, destroying tissue architecture and driving organ failure. Here we discover a …

Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

Strategies to manipulate immune cell co-inhibitory or co-activating signals have
revolutionized immunotherapy. However, certain immunologically cold diseases, such as …

Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate
disease in most patients but carries a risk of morbidity and mortality. Seriously affected …

Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …

Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as
key regulators of the inflammatory response under sterile and infectious conditions. Both …

The inflammasomes control the bioactivity of pro-inflammatory cytokines of the interleukin
(IL)-1 family. The inflammasome assembled by NLRP3 has been predominantly studied in …