The inactivation of programmed cell death, or apoptosis, is central to the development of
cancer. This disabling of apoptotic responses might be a major contributor both to treatment …

Defects in cell-death pathways are hallmarks of cancer. Although resistance to apoptosis is
closely linked to tumorigenesis, tumour cells can still be induced to die by non-apoptotic …

Acute exposure to ionizing radiation induces massive cell death and severe damage to
tissues containing actively proliferating cells, including bone marrow and the gastrointestinal …

Gastrointestinal (GI) tract damage by chemotherapy or radiation limits their efficacy in cancer
treatment. Radiation has been postulated to target epithelial stem cells within the crypts of …

Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise
mechanism of this suppression remains to be defined. Using a novel inducible Ahcre …

Each cell is under constant surveillance to maintain the integrity of its genome. Genomic
lesions in a cell must be repaired before the onset of DNA replication and cell division. In the …

Exposure of human tumor cell lines to different chemotherapeutic drugs, ionizing radiation,
and differentiating agents induced morphological, enzymatic, and ploidy changes …

The APC gene encodes the adenomatous polyposis coli tumour suppressor protein,
germline mutation of which characterizes familial adenomatous polyposis (FAP), an …

The mammalian intestinal mucosa, with its distinctive polarity, high rate of proliferation and
rapid cell migration, is an excellent model system to study proliferative hierarchies and the …

Purpose: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is
primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In …