The role of apoptosis in cancer development and treatment response
JM Brown, LD Attardi - Nature reviews cancer, 2005 - nature.com
The inactivation of programmed cell death, or apoptosis, is central to the development of
cancer. This disabling of apoptotic responses might be a major contributor both to treatment …
cancer. This disabling of apoptotic responses might be a major contributor both to treatment …
Pathways of apoptotic and non-apoptotic death in tumour cells
H Okada, TW Mak - Nature Reviews Cancer, 2004 - nature.com
Defects in cell-death pathways are hallmarks of cancer. Although resistance to apoptosis is
closely linked to tumorigenesis, tumour cells can still be induced to die by non-apoptotic …
closely linked to tumorigenesis, tumour cells can still be induced to die by non-apoptotic …
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
Acute exposure to ionizing radiation induces massive cell death and severe damage to
tissues containing actively proliferating cells, including bone marrow and the gastrointestinal …
tissues containing actively proliferating cells, including bone marrow and the gastrointestinal …
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
F Paris, Z Fuks, A Kang, P Capodieci, G Juan… - science, 2001 - science.org
Gastrointestinal (GI) tract damage by chemotherapy or radiation limits their efficacy in cancer
treatment. Radiation has been postulated to target epithelial stem cells within the crypts of …
treatment. Radiation has been postulated to target epithelial stem cells within the crypts of …
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
OJ Sansom, KR Reed, AJ Hayes, H Ireland… - Genes & …, 2004 - genesdev.cshlp.org
Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise
mechanism of this suppression remains to be defined. Using a novel inducible Ahcre …
mechanism of this suppression remains to be defined. Using a novel inducible Ahcre …
The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death.
A Basu, S Haldar - Molecular human reproduction, 1998 - academic.oup.com
Each cell is under constant surveillance to maintain the integrity of its genome. Genomic
lesions in a cell must be repaired before the onset of DNA replication and cell division. In the …
lesions in a cell must be repaired before the onset of DNA replication and cell division. In the …
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
BD Chang, EV Broude, M Dokmanovic, H Zhu, A Ruth… - Cancer research, 1999 - AACR
Exposure of human tumor cell lines to different chemotherapeutic drugs, ionizing radiation,
and differentiating agents induced morphological, enzymatic, and ploidy changes …
and differentiating agents induced morphological, enzymatic, and ploidy changes …
Myc deletion rescues Apc deficiency in the small intestine
OJ Sansom, VS Meniel, V Muncan, TJ Phesse… - Nature, 2007 - nature.com
The APC gene encodes the adenomatous polyposis coli tumour suppressor protein,
germline mutation of which characterizes familial adenomatous polyposis (FAP), an …
germline mutation of which characterizes familial adenomatous polyposis (FAP), an …
Stem cells in gastrointestinal epithelium: numbers, characteristics and death
CS Potten - … Transactions of the Royal Society of London …, 1998 - royalsocietypublishing.org
The mammalian intestinal mucosa, with its distinctive polarity, high rate of proliferation and
rapid cell migration, is an excellent model system to study proliferative hierarchies and the …
rapid cell migration, is an excellent model system to study proliferative hierarchies and the …
TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence
HD Skinner, VC Sandulache, TJ Ow, RE Meyn… - Clinical cancer …, 2012 - AACR
Purpose: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is
primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In …
primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In …