Biotin-dependent carboxylases include acetyl-CoA carboxylase (ACC), propionyl-CoA
carboxylase (PCC), 3-methylcrotonyl-CoA carboxylase (MCC), geranyl-CoA carboxylase …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

Corynebacterium glutamicum is an important organism in industrial biotechnology for the
microbial production of bulk chemicals, in particular amino acids. However, until now activity …

Proteasome inhibitors are rapidly evolving as potent treatment options in cancer therapy.
One of the most promising drug candidates of this type is salinosporamide A from the …

Mycobacteria are surrounded by a complex multilayered envelope and elongate at the
poles. The principles that organize the coordinated addition of chemically diverse cell wall …

Mycolic acids are vital components of the cell wall of the tubercle bacillus Mycobacterium
tuberculosis and are required for viability and virulence. While mycolic acid biosynthesis is …

Malonyl-CoA is an important central metabolite serving as the basic building block for the
microbial synthesis of many pharmaceutically interesting polyketides, but also fatty acid …

All organisms that produce fatty acids do so via a repeated cycle of reactions. In mammals
and other animals, these reactions are catalyzed by a type I fatty acid synthase (FAS), a …

Plants synthesize several thousand different polyphenols of which many have the potential
to aid in preventing or treating cancer, cardiovascular, and neurodegenerative diseases …