[HTML][HTML] An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds
O Ebenezer, MA Jordaan, G Carena, T Bono… - International Journal of …, 2022 - mdpi.com
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …
properties and hence have major pharmaceutical significance. They have an exceptional …
Discovery of anilino-1, 4-naphthoquinones as potent EGFR tyrosine kinase inhibitors: synthesis, biological evaluation, and comprehensive molecular modeling
P Mahalapbutr, R Leechaisit, A Thongnum… - ACS …, 2022 - ACS Publications
Epidermal growth factor receptor (EGFR) has been recognized as one of the attractive
targets for anticancer drug development. Herein, a set of anilino-1, 4-naphthoquinone …
targets for anticancer drug development. Herein, a set of anilino-1, 4-naphthoquinone …
[HTML][HTML] Design and Synthesis of New Hydantoin Acetanilide Derivatives as Anti-NSCLC Targeting EGFRL858R/T790M Mutations
Epidermal Growth Factor Receptor (EGFR), its wild type and mutations L858R/T790M, is
overexpressed in non-small cell lung cancer (NSCLC) patients and is considered an …
overexpressed in non-small cell lung cancer (NSCLC) patients and is considered an …
Intravenous Iron for Heart Failure: Updated Systematic Review and Meta-Analysis
W Techasatian, Y Nishimura, M Tanariyakul… - …, 2023 - journals.sagepub.com
While the administration of intravenous (IV) iron to those with heart failure has been
implicated to be associated with a possible reduction in hospitalizations and improvement in …
implicated to be associated with a possible reduction in hospitalizations and improvement in …
Exploration of novel dihydroquinoxalinone derivatives as EGFRL858R/T790M tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer
Y Cao, X Lu, L Fu, T Shi, C Zhang, L Zeng, J Zhang… - Bioorganic …, 2023 - Elsevier
To overcome or delay the drug-resistance of first-generation epidermal growth factor
receptor (EGFR) kinase inhibitors and non-selectivity toxicity mediated by second …
receptor (EGFR) kinase inhibitors and non-selectivity toxicity mediated by second …
Recent Insights into Osimertinib Analogues against EGFR Positive Non-small Cell Lung Cancer
J Chhabra, P Kashyap, R Pahwa… - Current Topics in …, 2023 - ingentaconnect.com
Background: Lung cancer is a highly lethal malignancy with a poor prognosis and the
leading cause of mortality worldwide. The development of mutations makes lung cancer …
leading cause of mortality worldwide. The development of mutations makes lung cancer …
Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing dihydroquinoxalinone as novel EGFRL858R/T790M kinase inhibitors against non …
L Fu, Y Cao, J Chen, R He, Y Zhao, Y Zhao, J Xi… - Medicinal Chemistry …, 2023 - Springer
The clinical responses to the EGFR kinase inhibitors in non-small cell lung cancer (NSCLC)
patients are always followed by drug-resistance mutations, including the gatekeeper T790M …
patients are always followed by drug-resistance mutations, including the gatekeeper T790M …
Potential of Heterocyclic Compounds as EGFR-TK Inhibitors in Cancer Therapy
Over the last few decades, cancer has become deadliest diseases worldwide. Vascular
Endothelial Growth Factor Receptor (VEGFR), Human Epidermal Growth Factor Receptor-2 …
Endothelial Growth Factor Receptor (VEGFR), Human Epidermal Growth Factor Receptor-2 …
A straightforward coupling of 4-sulfonylpyridines with Grignard reagents
LY Song, MK Chen, J Wang… - Journal of Chemical …, 2022 - journals.sagepub.com
A straightforward synthesis of alkyl-sulfonylpyridines and aryl-sulfonylpyridines is developed
by coupling of sulfonylpyridines with the Grignard reagents. The protocol proceeds through …
by coupling of sulfonylpyridines with the Grignard reagents. The protocol proceeds through …