Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

The concept that the immune system can communicate with peripheral sensory neurons to
modulate pain is based mostly on documented interactions between opioid ligands and …

Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable
nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 …

Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …

Although the endocannabinoid anandamide is frequently described to act predominantly in
the cardiovascular system, the molecular mechanisms of its signaling remained unclear. In …

Background: Chronic pain is a significant clinical problem and a very complex
pathophysiological phenomenon. There is growing evidence that targeting the …

The last decade has witnessed an explosion in novel findings relating to the molecules
involved in mediating the sensation of pain in humans. Transient receptor potential (TRP) …

Arachidonylethanolamide (anandamide) was identified some 15 years ago as a brain
constituent that binds to the cannabinoid receptor. After this seminal discovery, multiple new …

Despite the wealth of information on cannabinoid-induced peripheral antihyperalgesic and
antinociceptive effects in many pain models, the molecular mechanism (s) for these actions …

Potentiation of the pain‐integrator ion channel transient receptor potential vanilloid type 1
(TRPV1) underlies thermal hyperalgesia mediated by a variety of proinflammatory factors …