Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

Abstract Background and Aims Hypoxia is one of the central players in shaping the immune
context of the tumor microenvironment (TME). However, the complex interplay between …

Increasing chemotherapy delivery to tumors, while enhancing drug uptake and reducing
side effects, is a primary goal of cancer research. In mouse and human cancer models in …

Breast cancer has been the leading cause of female cancer deaths for decades. Intratumoral
hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is …

Posttranslational histone modifications serve to store epigenetic information and control both
nucleosome assembly and recruitment of non-histone proteins. Histone methylation occurs …

Purpose An overview of the Rapid Learning methodology, its results, and the potential
impact on radiotherapy. Material and results Rapid Learning methodology is divided into …

Accurate diagnosis of tumors and predicting the therapeutic responses are highly
demanded in the clinic to improve the treatment efficacy and survival rates. Since hypoxia …

Scientific advances have significantly improved the practice of medicine by providing
objective and quantitative means for exploring the human body and disease states. These …