Abstract Type 2 Diabetes Mellitus (T2D) is a chronic disease with a pandemic incidence
whose pathogenesis has not yet been clarified. Raising evidence highlighted the role of …

Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

Metabolic derangement with poor glycemic control accompanying overweight and obesity is
associated with chronic low-grade inflammation and hyperinsulinemia. Macrophages, which …

Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in
metabolic diseases such as type 2 diabetes. We report here that IR is incorporated into …

Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

Insulin is the master regulator of glucose, lipid, and protein metabolism. Following ingestion
of an oral glucose load or mixed meal, the plasma glucose concentration rises, insulin …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …

Although a large number of drugs are available for the treatment of type 2 diabetes mellitus
(T2DM), many patients do not achieve adequate disease control despite adhering to …

Type 2 diabetes (T2D) and obesity are relevant worldwide chronic diseases. A common
complication in both pathologies is the dysregulation of the insulin-signaling pathway that is …

Insulin resistance is present in one-quarter of the general population, predisposing these
people to a wide range of diseases. Our aim was to identify cell-intrinsic determinants of …