The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
Transforming the understanding of brain immunity
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …
immune functions. The diverse role of myeloid populations, including monocytes …
In vivo non-invasive confocal fluorescence imaging beyond 1,700 nm using superconducting nanowire single-photon detectors
Light scattering by biological tissues sets a limit to the penetration depth of high-resolution
optical microscopy imaging of live mammals in vivo. An effective approach to reduce light …
optical microscopy imaging of live mammals in vivo. An effective approach to reduce light …
Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders
INTRODUCTION The meninges are a three-layer membrane that covers the central nervous
system (CNS): The outermost layer, the dura mater, is attached onto the skull periosteum; …
system (CNS): The outermost layer, the dura mater, is attached onto the skull periosteum; …
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting
M Charabati, MA Wheeler, HL Weiner, FJ Quintana - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease
Communication within the glial cell ecosystem is essential for neuronal and brain health,–.
The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and …
The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and …
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
It remains unclear how immune cells from skull bone marrow niches are recruited to the
meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via …
meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via …
Brain borders at the central stage of neuroimmunology
J Rustenhoven, J Kipnis - Nature, 2022 - nature.com
The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …
the immune system. However, recent studies have highlighted the borders of the central …
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
Interactions between the immune and central nervous systems strongly influence brain
health. Although the blood–brain barrier restricts this crosstalk, we now know that meningeal …
health. Although the blood–brain barrier restricts this crosstalk, we now know that meningeal …