Metal-based photosensitizers as inducers of regulated cell death mechanisms

Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

Photon-controlled pyroptosis activation (photopyro): an emerging trigger for antitumor immune response

M Li, J Kim, H Rha, S Son, MS Levine… - Journal of the …, 2023 - ACS Publications
Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD)
characterized by the release of pro-inflammatory cytokines. Our knowledge of pyroptosis has …

Near‐Infrared Self‐Assembled Hydroxyl Radical Generator Based on Photoinduced Cascade Electron Transfer for Hypoxic Tumor Phototherapy

X Zhao, S He, J Wang, J Ding, S Zong, G Li… - Advanced …, 2023 - Wiley Online Library
The hydroxyl radical (• OH) is an extremely potent reactive oxygen species that plays a
crucial role in photooxidations within the realm of hypoxic tumor therapy. However, the …

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Q Lu, D Kou, S Lou, M Ashrafizadeh, AR Aref… - Journal of Hematology & …, 2024 - Springer
Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Surface modification of TiO 2 nanoparticles with organic molecules and their biological applications

FH Haghighi, M Mercurio, S Cerra… - Journal of Materials …, 2023 - pubs.rsc.org
In recent years, titanium (IV) dioxide nanoparticles (TiO2NPs) have shown promising
potential in various biological applications such as antimicrobials, drug delivery …

Disruption of Zinc Homeostasis by a Novel Platinum (IV)‐Terthiophene Complex for Antitumor Immunity

X Su, B Liu, WJ Wang, K Peng, BB Liang… - Angewandte …, 2023 - Wiley Online Library
Zinc homeostatic medicine is of great potential for cancer chemo‐immunotherapy; however,
there are few reports on antitumor compounds that can trigger Zn2+‐mediated immune …

A native drug-free macromolecular therapeutic to trigger mutual reinforcing of endoplasmic reticulum stress and mitochondrial dysfunction for cancer treatment

W Wang, Y Zhang, Z Wang, X Liu, S Lu, X Hu - ACS nano, 2023 - ACS Publications
Drug-free macromolecular therapeutics are promising alternatives to traditional drugs.
Nanomedicines with multiple organelles targeting can potentially increase the efficacy …

Biomaterials elicit pyroptosis enhancing cancer immunotherapy

MJ Zhang, YY Wang, LL Han, XY Liu… - Advanced Functional …, 2024 - Wiley Online Library
Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors,
but its effectiveness is limited by the low immune response rate and immune‐related …

Recent Progress in Photodynamic Immunotherapy with Metal‐Based Photosensitizers

K Xiong, F Wei, Y Chen, L Ji, H Chao - Small Methods, 2023 - Wiley Online Library
Cancer ranks as a leading cause of death. There is an urgent need to develop minimally
invasive methods to eradicate tumors and prevent their recurrence. As a light‐driven …

Four ounces can move a thousand pounds: the enormous value of nanomaterials in tumor immunotherapy

Z Chen, Z Yue, K Yang, C Shen… - Advanced …, 2023 - Wiley Online Library
The application of nanomaterials in healthcare has emerged as a promising strategy due to
their unique structural diversity, surface properties, and compositional diversity. In particular …