[HTML][HTML] Drug-induced oxidative stress in cancer treatments: angel or devil?

H Jiang, J Zuo, B Li, R Chen, K Luo, X Xiang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

[HTML][HTML] EMT mechanism in breast cancer metastasis and drug resistance: Revisiting molecular interactions and biological functions

M Hashemi, HZ Arani, S Orouei, S Fallah… - Biomedicine & …, 2022 - Elsevier
One of the malignant tumors in women that has involved both developed and developing
countries is breast cancer. Similar to other types of tumors, breast cancer cells demonstrate …

Cinnamon cassia oil chitosan nanoparticles: Physicochemical properties and anti-breast cancer activity

X Xu, Q Li, W Dong, G Zhao, Y Lu, X Huang… - International Journal of …, 2023 - Elsevier
The aim of this study was to prepare Cinnamomum cassia essential oil (CEO) impregnated
chitosan nanoparticles (CS-CEO) and assess its pharmacological activity against breast …

MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells

RB Soares, R Manguinhas, JG Costa, N Saraiva, N Gil… - Antioxidants, 2022 - mdpi.com
The manganese (III) porphyrin MnTnHex-2-PyP5+ (MnTnHex) is a potent superoxide
dismutase mimic and modulator of redox-based transcriptional activity that has been studied …

Gallic acid suppresses the progression of triple-negative breast cancer HCC1806 cells via modulating PI3K/AKT/EGFR and MAPK signaling pathways

S Lin, HZ Qin, ZY Li, H Zhu, L Long… - Frontiers in Pharmacology, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is a severe threat to women's health because of its
aggressive nature, early age of onset, and high recurrence rate. Therefore, in this study, we …

Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP5+ …

SU Noh, J Lim, SW Shin, Y Kim, WY Park… - Antioxidants, 2024 - mdpi.com
Manganese porphyrins reportedly exhibit synergic effects when combined with irradiation.
However, an in-depth understanding of intratumoral heterogeneity and immune pathways …

Cellular localization of selected porphyrins and their effect on the In Vitro motility of human colon tumors and normal cells

MP Frant, M Trytek, K Deryło, M Kutyła, R Paduch - Molecules, 2023 - mdpi.com
Standard therapies for colorectal cancer cannot eliminate or sufficiently reduce the
metastasis process. Photodynamic therapy (PDT) may be an alternative to minimizing this …

[HTML][HTML] Anticancer Effects of radiation dose and dose fractionation on X-ray-induced photodynamic therapy

R Li, P Gao, M Dai, F Xu, Z Tian, T Liu, J Zhou… - Journal of Radiation …, 2024 - Elsevier
Preclinical research has established X-ray-induced photodynamic therapy (X-PDT) as a
highly acknowledged antitumor therapy. X-rays play an important role in the X-PDT process …

Emerging Trends in Metal‐based Anticancer Agents: Drug Design to Clinical Trials and their Mechanism of Action

A Temesgen, HC Ananda Murthy, AZ Enyew… - …, 2023 - Wiley Online Library
Metal‐based therapeutic strategies have been effectively used to treat a number of diseases
since the ancient period. However, the issue that emerged at this time was the indistinct …

[HTML][HTML] 盐酸小檗碱通过激活EMT 促进小鼠乳腺癌肺转移的作用机制

袁志莹, 马恩, 沃达, 彭军, 朱伟东, 任丹妮 - 肿瘤防治研究, 2023 - html.rhhz.net
目的从上皮-间质转化(EMT) 途径探讨盐酸小檗碱(BBR) 对小鼠乳腺癌肺转移的作用及机制.
方法CCK-8 法检测BBR 对乳腺癌4T1 细胞增殖的影响; Transwell 实验检测BBR 对4T1 …