Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm‐associated infections

S Cascioferro, D Carbone, B Parrino… - …, 2021 - Wiley Online Library
Methicillin‐resistant Staphylococcus aureus (MRSA) has emerged as one of the leading
causes of persistent human infections. This pathogen is widespread and is able to colonize …

Antibiotic-induced biofilm formation

JB Kaplan - The International journal of artificial organs, 2011 - journals.sagepub.com
Surface-attached colonies of bacteria known as biofilms play a major role in the
pathogenesis of device-related infections. Biofilm colonies are notorious for their resistance …

[HTML][HTML] Concentration-dependent activity of antibiotics in natural environments

SP Bernier, MG Surette - Frontiers in microbiology, 2013 - frontiersin.org
Bacterial responses to antibiotics are concentration-dependent. At high concentrations,
antibiotics exhibit antimicrobial activities on susceptible cells, while subinhibitory …

Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus

JB Kaplan, EA Izano, P Gopal, MT Karwacki, S Kim… - MBio, 2012 - Am Soc Microbiol
Subminimal inhibitory concentrations of antibiotics have been shown to induce bacterial
biofilm formation. Few studies have investigated antibiotic-induced biofilm formation in …

[HTML][HTML] Manuka-type honeys can eradicate biofilms produced by Staphylococcus aureus strains with different biofilm-forming abilities

J Lu, L Turnbull, CM Burke, M Liu, DA Carter… - PeerJ, 2014 - peerj.com
Chronic wounds are a major global health problem. Their management is difficult and costly,
and the development of antibiotic resistance by both planktonic and biofilm-associated …

The role of antibiotics in modulating virulence in Staphylococcus aureus

E Hodille, W Rose, BA Diep, S Goutelle… - Clinical microbiology …, 2017 - Am Soc Microbiol
Staphylococcus aureus is often involved in severe infections, in which the effects of bacterial
virulence factors have great importance. Antistaphylococcal regimens should take into …

Polyhydroxyanthraquinones as Quorum Sensing Inhibitors from the Guttates of Penicillium restrictum and Their Analysis by Desorption Electrospray Ionization Mass …

M Figueroa, AK Jarmusch, HA Raja… - Journal of natural …, 2014 - ACS Publications
The endophytic fungus Penicillium restrictum was isolated from the stems of a milk thistle
(Silybum marianum) plant. In culture, the fungus produced distinct red guttates, which have …

A combined pharmacodynamic quantitative and qualitative model reveals the potent activity of daptomycin and delafloxacin against Staphylococcus aureus biofilms

J Bauer, W Siala, PM Tulkens… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Biofilms are associated with persistence of Staphylococcus aureus infections and
therapeutic failures. Our aim was to set up a pharmacodynamic model comparing antibiotic …

[HTML][HTML] Sub-minimum inhibitory concentrations of colistin and polymyxin B promote Acinetobacter baumannii biofilm formation

Y Sato, Y Unno, T Ubagai, Y Ono - PLoS One, 2018 - journals.plos.org
We investigated the numbers of planktonic and biofilm cells and the expression levels of
genes encoding efflux pumps and biofilm-related proteins in 10 clinical isolates of multi-drug …

Antibacterial surface design of titanium-based biomaterials for enhanced bacteria-killing and cell-assisting functions against periprosthetic joint infection

J Wang, J Li, S Qian, G Guo, Q Wang… - … applied materials & …, 2016 - ACS Publications
Periprosthetic joint infection (PJI) is one of the formidable and recalcitrant complications after
orthopedic surgery, and inhibiting biofilm formation on the implant surface is considered …