Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

AL Mora, M Rojas, A Pardo, M Selman - Nature reviews Drug discovery, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

[HTML][HTML] Connective tissue growth factor: from molecular understandings to drug discovery

Z Chen, N Zhang, HY Chu, Y Yu, ZK Zhang… - Frontiers in cell and …, 2020 - frontiersin.org
Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved
in different biological processes, such as cell proliferation, angiogenesis, and wound …

Molecular and tissue alterations of collagens in fibrosis

S Ricard-Blum, G Baffet, N Théret - Matrix Biology, 2018 - Elsevier
The collagen network is altered in fibrotic diseases associated with extracellular matrix
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …

Targeting hypoxia-inducible factor-1α/pyruvate dehydrogenase kinase 1 axis by dichloroacetate suppresses bleomycin-induced pulmonary fibrosis

J Goodwin, H Choi, M Hsieh, ML Neugent… - American journal of …, 2018 - atsjournals.org
Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly
activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how …

Vitamin C in stem cell biology: impact on extracellular matrix homeostasis and epigenetics

CD′ Aniello, F Cermola, EJ Patriarca… - Stem cells …, 2017 - Wiley Online Library
Transcription factors and signaling molecules are well‐known regulators of stem cell identity
and behavior; however, increasing evidence indicates that environmental cues contribute to …

[HTML][HTML] A systematic review of the role of dysfunctional wound healing in the pathogenesis and treatment of idiopathic pulmonary fibrosis

A Betensley, R Sharif, D Karamichos - Journal of clinical medicine, 2016 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disorder
showcasing an interaction between genetic predisposition and environmental risks. This …

[HTML][HTML] Pre-vascularization enhances therapeutic effects of human mesenchymal stem cell sheets in full thickness skin wound repair

L Chen, Q Xing, Q Zhai, M Tahtinen, F Zhou, L Chen… - Theranostics, 2017 - ncbi.nlm.nih.gov
Split thickness skin graft (STSG) implantation is one of the standard therapies for full
thickness wound repair when full thickness autologous skin grafts (FTG) or skin flap …

[HTML][HTML] Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression

B Tampe, U Steinle, D Tampe, JL Carstens, P Korsten… - Kidney international, 2017 - Elsevier
Acute kidney injury (AKI) and progressive chronic kidney disease (CKD) are intrinsically tied
syndromes. In this regard, the acutely injured kidney often does not achieve its full …

Reactive oxygen species drive epigenetic changes in radiation‐induced fibrosis

S Shrishrimal, EA Kosmacek… - … medicine and cellular …, 2019 - Wiley Online Library
Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …

Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension

M Zhang, W Xin, Y Yu, X Yang, C Ma, H Zhang… - Journal of molecular and …, 2020 - Elsevier
Pyroptosis is a pro-inflammatory form of programmed cell death, whose genesis directly
depended on caspase-1 activation. Pulmonary hypertension (PH) is a disease …