Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Over the past decade, there has been a transformation in the portfolio of medicines to
combat malaria. New fixed-dose artemisinin combination therapy is available, with four …

Differences in cannabis (Cannabis sativa L.) plant chemistry between strains are influenced
by genetics, plant growth and development, in addition to environmental conditions such as …

Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …

To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the
causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2 C-methyl …

Plasmodium liver hypnozoites, which cause disease relapse, are widely considered to be
the last barrier towards malaria eradication. The biology of this quiescent form of the parasite …

Malaria is the most lethal and debilitating disease caused by the protozoan parasite
Plasmodium worldwide. The most severe forms of disease and the incidence rates of …

In the present manuscript, we describe how we successfully used ligand-based virtual
screening (LBVS) to identify two small-molecule, drug-like hit classes with excellent ADMET …

Malaria parasites rely on a plastid organelle for survival during the blood stages of infection.
However, the entire organelle is dispensable as long as the isoprenoid precursor …