What is new in cancer-associated fibroblast biomarkers?

Z Zhao, T Li, Y Yuan, Y Zhu - Cell Communication and Signaling, 2023 - Springer
The tumor microenvironment is one of the important drivers of tumor development. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and actively …

The role of cancer-associated fibroblasts in ovarian cancer

M Zhang, Z Chen, Y Wang, H Zhao, Y Du - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is a lethal gynecologic tumor and is generally resistant to
conventional treatments. Stable cancer-associated fibroblasts (CAFs) are important cellular …

Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling

SC Lin, YC Liao, PM Chen, YY Yang, YH Wang… - Journal of Biomedical …, 2022 - Springer
Background Ovarian cancer has the highest mortality among gynecological cancers due to
late diagnosis and lack of effective targeted therapy. Although the study of interplay between …

Single‐nucleus RNA sequencing and spatial transcriptomics reveal the immunological microenvironment of cervical squamous cell carcinoma

Z Ou, S Lin, J Qiu, W Ding, P Ren, D Chen… - Advanced …, 2022 - Wiley Online Library
The effective treatment of advanced cervical cancer remains challenging. Herein, single‐
nucleus RNA sequencing (snRNA‐seq) and SpaTial enhanced resolution omics …

Omental cancer‐associated fibroblast‐derived exosomes with low microRNA‐29c‐3p promote ovarian cancer peritoneal metastasis

Q Han, S Tan, L Gong, G Li, Q Wu, L Chen… - Cancer …, 2023 - Wiley Online Library
Ovarian cancer (OC) is characterized by frequent widespread peritoneal metastasis. Cancer‐
associated fibroblasts (CAFs) represent a critical stromal component of metastatic niche and …

Periostin: an emerging activator of multiple signaling pathways

Z Wang, J An, D Zhu, H Chen, A Lin, J Kang… - Journal of cell …, 2022 - Springer
Matricellular proteins are responsible for regulating the microenvironment, the behaviors of
surrounding cells, and the homeostasis of tissues. Periostin (POSTN), a non-structural …

[HTML][HTML] Cancer-associated fibroblasts: Key criminals of tumor pre-metastatic niche

G Dong, P Chen, Y Xu, T Liu, R Yin - Cancer Letters, 2023 - Elsevier
Cancer-associated fibroblasts (CAFs) are abundant and important components of the
tumour mesenchyme, and have been extensively studied for their role in primary tumours …

TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells

Q Ping, C Wang, X Cheng, Y Zhong, R Yan… - Journal of Translational …, 2023 - Springer
Background Bladder cancer is one of the most common malignant tumors of the urinary
system and is associated with a poor prognosis once invasion and distant metastases occur …

The transcoelomic ecosystem and epithelial ovarian cancer dissemination

SJ Ritch, CM Telleria - Frontiers in Endocrinology, 2022 - frontiersin.org
Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is
normally diagnosed at late stages, at which point metastasis has already occurred …

Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy

J Linares, A Sallent-Aragay, J Badia-Ramentol… - Nature …, 2023 - nature.com
A substantial proportion of cancer patients do not benefit from platinum-based
chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental …