The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …

The endoplasmic reticulum (ER) produces the vast majority of all proteins secreted into the
extracellular space, including hormones and cytokines, as well as cell surface receptors and …

The unfolded protein response (UPR) is a highly conserved protein quality control
mechanism, activated in response to Endoplasmic Reticulum (ER) stress. Signalling is …

Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading
to the progressive decline of motor control due to the loss of dopaminergic neurons in the …

Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …

Loss of protein folding homeostasis features many of the most prevalent neurodegenerative
disorders. As coping mechanism to folding stress within the endoplasmic reticulum (ER), the …