Drug repurposing is considered a valid approach to accelerate therapeutic solutions for rare
diseases. However, it is not as widely applied as it could be, due to several barriers that …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by
progressive motor neuron degeneration, muscle weakness, paralysis, and ultimately death …

Introduction: Cachexia is a complex metabolic syndrome associated with underlying illness
and characterized by loss of muscle with or without loss of fat mass. Systemic inflammation …

Hitherto, membralin has been a protein of unknown function. Here, we show that membralin
mutant mice manifest a severe and early-onset motor neuron disease in an autosomal …

ALS is a fatal untreatable disease involving degeneration of motor neurons. Μultiple
causative genes encoding proteins with versatile functions have been identified indicating …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
afflicting motor neurons (MNs) of the spinal cord, brainstem, and motor cortex, leading to …

Cellular stress caused by protein misfolding, aggregation and redox imbalance is typical of
neurodegenerative disorders such as Parkinson's disease (PD) and Amyotrophic Lateral …

Endoplasmic reticulum (ER) stress is a prominent cellular alteration of diseases impacting
the nervous system that are associated to the accumulation of misfolded and aggregated …

Many of the major neurodegenerative disorders are characterized by the accumulation of
intracellular protein aggregates in neurons and other cells in brain, suggesting that errors in …

Endoplasmic reticulum (ER) stress can take place due to the disruptions in the structure and
functions of ER, along with the changes in calcium homeostasis and buildup of misfolded …