Solving ion channel kinetics with the QuB software

C Nicolai, F Sachs - Biophysical Reviews and Letters, 2013 - World Scientific
The ability to record the currents from single ion channels led to the need to extract the
underlying kinetic model from such data. This inverse hidden Markov problem is difficult but …

Stochastic models for ion channels: introduction and bibliography

FG Ball, JA Rice - Mathematical biosciences, 1992 - Elsevier
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The principles of the stochastic interpretation of ion-channel mechanisms

D Colquhoun, AG Hawkes - Single-channel recording, 1995 - Springer
Most mechanisms that are considered for ion channels (as for any other sort of chemical
reaction) involve reversible transitions among the various possible discrete chemical states …

Control of NMDA receptor function by the NR2 subunit amino-terminal domain

H Yuan, KB Hansen, KM Vance, KK Ogden… - Journal of …, 2009 - Soc Neuroscience
NMDA receptors comprised of different NR2 subunits exhibit strikingly unique biophysical
and pharmacological properties. Here, we report that the extracellular amino-terminal …

Neurosteroid regulation of GABAA receptor single‐channel kinetic properties of mouse spinal cord neurons in culture.

RE Twyman, RL Macdonald - The Journal of physiology, 1992 - Wiley Online Library
1. Single‐channel kinetics of steroid enhancement of single gamma‐aminobutyric acidA
(GABA) receptor currents obtained from somata of mouse spinal cord neurones in culture …

Activation of NR1/NR2b NMDA Receptors

TG Banke, SF Traynelis - Nature neuroscience, 2003 - nature.com
Abstract N-methyl-d-aspartate (NMDA) receptors are highly expressed in the central nervous
system and are involved in excitatory synaptic transmission as well as synaptic plasticity …

De novo GRIN variants in NMDA receptor M2 channel pore‐forming loop are associated with neurological diseases

J Li, J Zhang, W Tang, RK Mizu, H Kusumoto… - Human …, 2019 - Wiley Online Library
N‐methyl‐D‐aspartate receptors (NMDARs) mediate slow excitatory postsynaptic
transmission in the central nervous system, thereby exerting a critical role in neuronal …

Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens

V Burzomato, M Beato, PJ Groot-Kormelink… - Journal of …, 2004 - Soc Neuroscience
The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine
receptors in the adult. Their activation mechanism was investigated by fitting putative …

Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents

R Kazi, J Dai, C Sweeney, HX Zhou… - Nature neuroscience, 2014 - nature.com
The fidelity of integration of pre-and postsynaptic activity by NMDA receptors (NMDARs)
requires a match between agonist binding and ion channel opening. To address how …

Accounting for the Ca (2+)‐dependent kinetics of single large‐conductance Ca (2+)‐activated K+ channels in rat skeletal muscle.

OB McManus, KL Magleby - The Journal of physiology, 1991 - Wiley Online Library
1. The Ca (2+)‐dependent kinetics of large‐conductance Ca (2+)‐activated K+ channels
from cultured rat skeletal muscle were studied with the patch clamp technique. Data were …