Hemodiafiltration to address unmet medical needs ESKD patients

B Canaud, J Vienken, S Ash - … Journal of the American Society of …, 2018 - journals.lww.com
Hemodiafiltration combines diffusive and convective solute removal in a single therapy by
ultrafiltering 20% or more of the blood volume processed using a high-flux hemodialyzer …

Updates on hemodialysis techniques with a common denominator: The personalization of the dialytic therapy

P Monardo, A Lacquaniti, S Campo… - Seminars in …, 2021 - Wiley Online Library
Hemodialysis (HD) is a life‐saving therapy for patients with end‐stage renal disease. In
dialyzed patients, the prevalence of multi‐morbidity is rising driven by various factors, such …

Citrate anion improves chronic dialysis efficacy, reduces systemic inflammation and prevents Chemerin-mediated microvascular injury

S Dellepiane, D Medica, C Guarena, T Musso… - Scientific Reports, 2019 - nature.com
Systemic inflammation and uremic toxins (UT) determine the increased cardiovascular
mortality observed in chronic hemodialysis (HD) patients. Among UT, the adipokine …

Regional Citrate Anticoagulation: A Tale of More Than Two Stories

T Demuynck, M Grooteman, P Ter Wee… - Seminars in …, 2024 - Elsevier
Calcium is a key clotting factor, and several inorganic molecules that bind to calcium have
been found to reduce the clotting propensity of blood. Citrate, a calcium chelator, is used as …

Citric-acid dialysate improves the calcification propensity of hemodialysis patients: A multicenter prospective randomized cross-over trial

KJ Ter Meulen, MJE Dekker, A Pasch, NJH Broers… - PLoS …, 2019 - journals.plos.org
Introduction The concentration of dialysate calcium (dCa) has been suggested to affect
vascular calcification, but evidence is scarce. Calcification propensity reflects the intrinsic …

Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study “Hephaestus”

F Pizzarelli, V Cantaluppi, V Panichi, A Toccafondi… - Journal of …, 2021 - Springer
Background Studies addressing the anti-inflammatory properties of citrate dialysate enrolled
patients in both hemodialysis (HD) and hemodiafiltration (HDF), the latter not adjusted for …

Advanced hemodialysis equipment for more eco-friendly dialysis

A Gauly, N Fleck, F Kircelli - International urology and nephrology, 2022 - Springer
Healthcare in general and dialysis care in particular are contributing to resource
consumption and, thus, have a notable environmental footprint. Dialysis is a life-saving …

Monitoring of ionized magnesium in hemodialysis patients: A useful tool to allow a personalized prescription of dialysate composition

AS Bargnoux, M Morena, A Rodriguez… - Clinica Chimica …, 2024 - Elsevier
Background and aims The dialysate magnesium (Mg) concentration is a major determinant
of Mg balance in hemodialysis. This study aimed to assess the systemic variations of total …

Long-term effects of citric acid-based bicarbonate haemodialysis on patient outcomes: a survival propensity score–matched study in western France

J Potier, T Dolley-Hitze, D Hamel… - Nephrology Dialysis …, 2020 - academic.oup.com
Background Citric acid–based bicarbonate haemodialysis (CIT-HD) has gained more
clinical acceptance over the last few years in France and is a substitute for other acidifiers …

[HTML][HTML] Advantages of the use of citrate over acetate as a stabilizer in hemodialysis fluid: A randomized ABC-treat study

P de Sequera, R Pérez-García, M Molina… - Nefrología (English …, 2022 - Elsevier
Hemodialysis (HD) with bicarbonate dialysis fluid (DF) requires the presence of an acid to
prevent the precipitation of calcium and magnesium carbonate. The most used acid is acetic …