DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …

Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

Over the last few decades, the prevalence of obesity has risen to epidemic proportions
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …

We propose a model for obesity development that traces a considerable part of its origins to
the social domain (mainly different forms of prolonged social adversity), both within and …

Fetal metabolic programming caused by the adverse intrauterine environment can induce
metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal …

Early life is an important window of opportunity to improve health across the full lifecycle. An
accumulating body of evidence suggests that exposure to adverse stressors during early life …

Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

Background Higher maternal plasma glucose (PG) concentrations, even below gestational
diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with …