Ecologically mediated selection against hybrids, caused by hybrid phenotypes fitting poorly
into available niches, is typically viewed as distinct from selection caused by epistatic …

Engineering proteins and enzymes with the desired functionality has broad applications in
molecular biology, biotechnology, biomedical sciences, health, and medicine. The vastness …

Interactions between mutations (epistasis) can add substantial complexity to genotype-
phenotype maps, hampering our ability to predict evolution. Yet, recent studies have shown …

Dominance is usually considered a constant value that describes the relative difference in
fitness or phenotype between heterozygotes and the average of homozygotes at a focal …

Fitness landscape theory predicts that rugged landscapes with multiple peaks impair
Darwinian evolution, but experimental evidence is limited. In this study, we used genome …

The evolution of antimicrobial resistance (AMR) in bacteria is a major public health concern,
and antibiotic restriction is often implemented to reduce the spread of resistance. These …

Organisms have evolved a range of constitutive (always active) and inducible (elicited by
parasites) defence mechanisms, but we have limited understanding of what drives the …

Mutations that enhance evolvability may open doors to faster adaptation | Nature
Communications Skip to main content Thank you for visiting nature.com. You are using a browser …

The many functions of microbial communities emerge from a complex web of interactions
between organisms and their environment. This poses a significant obstacle to engineering …

Predicting mutational effects is essential for the control of antibiotic resistance (ABR).
Predictions are difficult when there are strong genotype-by-environment (G× E), gene-by …