[HTML][HTML] The role of the CXCL12/CXCR4/CXCR7 chemokine axis in cancer
Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
Tumor microenvironment: Sanctuary of the devil
L Hui, Y Chen - Cancer letters, 2015 - Elsevier
Tumor cells constantly interact with the surrounding microenvironment. Increasing evidence
indicates that targeting the tumor microenvironment could complement traditional treatment …
indicates that targeting the tumor microenvironment could complement traditional treatment …
[PDF][PDF] Inhibition of amino acid metabolism selectively targets human leukemia stem cells
In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem
cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino …
cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino …
[PDF][PDF] Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche
Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for
normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we …
normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we …
The intricate role of CXCR4 in cancer
Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks
Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …
Cryo-shocked cancer cells for targeted drug delivery and vaccination
Live cells have been vastly engineered into drug delivery vehicles to leverage their targeting
capability and cargo release behavior. Here, we describe a simple method to obtain …
capability and cargo release behavior. Here, we describe a simple method to obtain …
Cancer stem cell definitions and terminology: the devil is in the details
P Valent, D Bonnet, R De Maria, T Lapidot… - Nature Reviews …, 2012 - nature.com
The cancer stem cell (CSC) concept has important therapeutic implications, but its
investigation has been hampered both by a lack of consistency in the terms used for these …
investigation has been hampered both by a lack of consistency in the terms used for these …
[HTML][HTML] A review on CXCR4/CXCL12 axis in oncology: no place to hide
UM Domanska, RC Kruizinga, WB Nagengast… - European journal of …, 2013 - Elsevier
Classical chemotherapeutic anti-cancer treatments induce cell death through DNA damage
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …
Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies
Summary On July 1, 2014, the United States Food and Drug Administration granted
'breakthrough therapy'designation to CTL 019, the anti‐CD 19 chimeric antigen receptor T …
'breakthrough therapy'designation to CTL 019, the anti‐CD 19 chimeric antigen receptor T …