Abstract Disease Overview: Acute myeloid leukemia (AML) results from accumulation of
abnormal immature cells in the marrow. These cells interfere with normal hematopoiesis can …

Dynamic interactions between leukaemic cells and cells of the bone marrow are a feature of
haematological malignancies. Two distinct microenvironmental niches in the bone marrow …

Leukemia is a hematological malignancy associated with the uncontrolled proliferation of
mutant progenitors, suppressing the production of normal blood cells. Current treatments …

The induction of polyploidy is considered the reproductive end of cells, but there is evidence
that polyploid giant cancer cells (PGCCs) contribute to cell repopulation during tumor …

Objectives: To summarize the effects of the bone marrow niche on hematopoiesis and
leukemogenesis and discuss the chemotherapy resistance that can arise from interactions …

Despite an increasingly rich understanding of its pathogenesis, acute myeloid leukemia
remains a disease with poor outcomes, overwhelmingly due to disease relapse. In recent …

Accumulated evidence has demonstrated that the microenvironment of a given tumor is
important in determining its drug resistance, tumorigenesis, progression and metastasis …

Interactions within the hematopoietic niche in the BM microenvironment are essential for
maintenance of the stem cell pool. In addition, this niche is thought to serve as a sanctuary …

Abstract Treatment choices for acute myelogenous leukemia (AML) patients resistant to
conventional chemotherapies are limited and novel therapeutic agents are needed. IL3 …

Hematopoietic stem cells (HSC), including umbilical cord blood CD34+ stem cells (UCB-
CD34+), are used for the treatment of several diseases. Although different studies suggest …