Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …

The purposes of the review are to: a) Provide a comprehensible introduction of the-state-
ofthe-art sciences of solubility and dissolution, b) introduce typical technologies to assess …

The present work deals with improving the solubility of vemurafenib, a practically insoluble
drug, by converting it into an amorphous-solid dispersion using a solventcontrolled …

Lipid excipients are attracting interest from drug developers due to their performance, ease
of use, versatility and their potential to generate intellectual property through innovation in …

Telmisartan (TEL) is a BCS Class II drug having dissolution rate limited bioavailability. The
aim of work was to enhance the solubility of TEL so that bioavailability problems are solved …

Linaclotide, a potent guanylate cyclase C agonist, is a therapeutic peptide approved in the
United States for the treatment of irritable bowel syndrome with constipation and chronic …

Purpose The objectives of the study was to develop a dissolution test method that can be
used to predict the oral absorption of montelukast sodium, and to establish an in vitro/in vivo …

Compromised oral drug absorption, due to poor aqueous solubility, is one of the major
challenges faced by the pharmaceutical industry in the drug discovery and development …

Biphasic dissolution systems achieved good predictability for the in vivo performance of
several formulations of poorly water-soluble drugs by characterizing dissolution …

The purpose of this study was to optimize the melt granulation process of fenofibrate using
twin-screw granulator. Initial screening was performed to select the excipients required for …