Mechanisms of intestinal pharmacokinetic natural product-drug interactions
VO Oyanna, JD Clarke - Drug Metabolism Reviews, 2024 - Taylor & Francis
The growing co-consumption of botanical natural products with conventional medications
has intensified the need to understand potential effects on drug safety and efficacy. This …
has intensified the need to understand potential effects on drug safety and efficacy. This …
[HTML][HTML] Neither an Individualised Nor a Standardised Sodium Bicarbonate Strategy Improved Performance in High-Intensity Repeated Swimming, or a Subsequent …
Inconsistent swimming performances are often observed following sodium bicarbonate
(NaHCO3) ingestion, possibly because the time taken to reach peak blood buffering …
(NaHCO3) ingestion, possibly because the time taken to reach peak blood buffering …
Physiologically-based pharmacokinetic-pharmacodynamics model characterizing CYP2C19 polymorphisms to predict clopidogrel pharmacokinetics and its anti …
R Xu, W Kong, X An, J Zou, L Liu, X Liu - Frontiers in Pharmacology, 2020 - frontiersin.org
Background and Objective: Clopidogrel (CLOP) is commonly used in coronary artery
disease (CAD) patients with or without diabetes (DM), but these patients often suffer CLOP …
disease (CAD) patients with or without diabetes (DM), but these patients often suffer CLOP …
Physiologically based absorption modeling to predict the bioequivalence of two cilostazol formulations
L Wang, P Zhao, T Luo, D Yang, Q Jiang… - Clinical and …, 2023 - Wiley Online Library
In vivo pharmacokinetic simulations and virtual bioequivalence (BE) evaluation of cilostazol
have not yet been described for humans. Here, we successfully developed a physiologically …
have not yet been described for humans. Here, we successfully developed a physiologically …
Exploration of Abiraterone acetate loaded Nanostructured lipid carriers for bioavailability improvement and circumvention of fast-fed variability
Abiraterone acetate (ABA), a biopharmaceutical class IV drug suffers from solubility and
permeability pitfalls resulting in limited oral bioavailability and positive food effect, ie multi …
permeability pitfalls resulting in limited oral bioavailability and positive food effect, ie multi …
Comparative metabolism of the eight main bioactive ingredients of gegen qinlian decoction by the intestinal flora of diarrhoeal and healthy piglets
CS Liu, X Liang, XH Wei, FL Chen… - Biomedical …, 2019 - Wiley Online Library
Diarrhoeal diseases alter the composition of intestinal flora, thereby affecting the efficacy of
herbal medicinal formulations. Gegen Qinlian decoction (GQD), a Chinese traditional herbal …
herbal medicinal formulations. Gegen Qinlian decoction (GQD), a Chinese traditional herbal …
In-vitro–in-silico investigation of the negative food effect of zolpidem when administered as immediate-release tablets
RLM Paraiso, A Watanabe, CJ Andreas… - Journal of Pharmacy …, 2019 - academic.oup.com
Objectives The main objective of the present work was to combine in-vitro and in-silico tools
to better understand the in-vivo behavior of the immediate release (IR) formulation of …
to better understand the in-vivo behavior of the immediate release (IR) formulation of …
Antituberculosis macozinone extended-release tablets to enhance bioavailability: a pilot pharmacokinetic study in beagle dogs
A Koryakova, V Shcherbakova, O Riabova… - Microbiology …, 2023 - Am Soc Microbiol
ABSTRACT Macozinone (MCZ; PBTZ169) is a first-in-class antituberculosis clinical-stage
benzothiazinone-based drug candidate. Although its efficacy and safety have been strongly …
benzothiazinone-based drug candidate. Although its efficacy and safety have been strongly …
Negative food effect of danirixin: use of PBPK modelling to explore the effect of formulation and meal type on clinical PK
RS Lloyd, MI Hingle, JC Bloomer, SJ Charles… - Pharmaceutical …, 2020 - Springer
Purpose To use physiologically-based pharmacokinetic (PBPK) modelling to explore the
food effect of different DNX hydrobromide (HBr) hemihydrate salt tablet formulations using …
food effect of different DNX hydrobromide (HBr) hemihydrate salt tablet formulations using …
Gastroprotective Effects of Biological Macromolecule: Polysaccharides
The large molecular weight of the macromolecules sets them apart from all other
components. This may range from 10 000 to over a million. While the molecular weight of …
components. This may range from 10 000 to over a million. While the molecular weight of …