OBJECTIVE: To elucidate the potential function of long non-coding RNA (lncRNA) TUG1 in
the progression of diabetic nephropathy (DN) and the underlying mechanism. MATERIALS …

The purpose of this study was to investigate the renal protective effect of celastrol on diabetic
rats. Furthermore, the mechanism of its action was discussed whether it was related to …

In this study the role of CXCL6 in diabetic nephropathy (DN) was investigated. It was found
to be overexpression in DN patients and DN rat model. And the expression of fibrosis …

Immune cell infiltration (ICI) plays a pivotal role in the development of diabetic nephropathy
(DN). Evidence suggests that immune-related genes play an important role in the initiation of …

Over decades, substantial progress has been achieved in understanding the pathogenesis
of proteinuria in diabetic kidney disease (DKD), biomarkers for DKD screening, diagnosis …

SGLT2 inhibitor-related nephroprotection is—at least partially—mediated by anti-
inflammatory drug effects, as previously demonstrated in diabetic animal and human …

Diabetic kidney disease (DKD) is the principal cause of end-stage renal disease worldwide
and few treatments are available. Because immunomodulators are pivotal to DKD …

Type 2 diabetes mellitus (T2DM) is a chronic disease that has become a global public health
problem. Studies on T2DM prevention and treatment mostly focus on discovering …

Phosphatase and tensin homolog (PTEN) is a potent tumor suppressor gene that
antagonizes the proto-oncogenic phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) …

Theaflavins are characteristic ingredients of black tea which are correlated with their
qualities and functions. The study aimed to evaluate the effects and mechanism of major …