Uterine fibroids (leiomyomas or myomas) are the most frequent benign tumors in women.
Heavy menstrual bleeding with resultant anemia, dysmenorrhea, chronic pelvic pain …

Polycystic ovary syndrome (PCOS) and endometriosis are reproductive disorders that may
cause infertility. The pathology of both diseases has been suggested to be associated with …

Abnormal uterine bleeding (AUB) is a chronic, debilitating and common condition affecting
one in four women of reproductive age. Current treatments (conservative, medical and …

This randomized, double‐blind, parallel‐group study in healthy young women investigated
the effect of treatment with vilaprisan (0.5, 1, 2, or 4 mg/day for 12 weeks) on ovarian function …

Aims The primary aim of the present study was to quantify the effects of rifampicin, a strong
cytochrome P450 (CYP) 3A4 inducer, on the pharmacokinetics of the new selective …

Background and objectives In-vitro data suggest that clearance of vilaprisan is mediated by
cytochrome P450 3A4 (oxidation) and aldoketoreductases (reduction). To fully understand …

This is a preliminary report of the first cases of successful simultaneous use of ulipristal
acetate (UPA) and vitamin D3 in uterine fibroid (UF) oral treatment in humans. We present …

Introduction Endometriosis is a benign disease, characterized by a wide range of symptoms
and different degrees of severity, which is why therapy should be individually adapted to the …

Introduction: The medical strategy to antagonize myoma size and related-symptoms is to
reduce estrogen and progesterone activity on myomas. This can be obtained with the GnRH …

Background Heavy menstrual bleeding (HMB) detrimentally effects women. It is important to
be able to compare treatments and synthesise data to understand which interventions are …