Lung cancer staging and prognosis

GA Woodard, KD Jones, DM Jablons - Lung cancer: treatment and …, 2016 - Springer
The seventh edition of the non-small cell lung cancer (NSCLC) TNM staging system was
developed by the International Association for the Staging of Lung Cancer (IASLC) Lung …

Predictive biomarkers in PD-1/PD-L1 checkpoint blockade immunotherapy

X Meng, Z Huang, F Teng, L Xing, J Yu - Cancer treatment reviews, 2015 - Elsevier
Checkpoint blockades turn on a new paradigm shift in immunotherapy for cancer.
Remarkable clinical efficacy, durable response and low toxicity of programmed death 1 (PD …

Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

DH Kim, HR Kim, YJ Choi, SY Kim, JE Lee… - … & molecular medicine, 2019 - nature.com
Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway
blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded …

[HTML][HTML] Pembrolizumab for the treatment of non–small-cell lung cancer

EB Garon, NA Rizvi, R Hui, N Leighl… - … England Journal of …, 2015 - Mass Medical Soc
Background We assessed the efficacy and safety of programmed cell death 1 (PD-1)
inhibition with pembrolizumab in patients with advanced non–small-cell lung cancer …

Soluble PD-L1 is a predictive and prognostic biomarker in advanced cancer patients who receive immune checkpoint blockade treatment

SY Oh, S Kim, B Keam, TM Kim, DW Kim, DS Heo - Scientific reports, 2021 - nature.com
Circulating soluble programmed death-1 ligand (sPD-L1) is measurable in the serum of
cancer patients. This study aimed to investigate the significance of sPD-L1 in cancer patients …

Immune checkpoint pathways in immunotherapy for head and neck squamous cell carcinoma

Z Mei, J Huang, B Qiao, AK Lam - International journal of oral science, 2020 - nature.com
With the understanding of the complex interaction between the tumour microenvironment
and immunotherapy, there is increasing interest in the role of immune regulators in the …

Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of …

L Carbognin, S Pilotto, M Milella, V Vaccaro, M Brunelli… - PloS one, 2015 - journals.plos.org
Background The potential predictive role of programmed death-ligand-1 (PD-L1) expression
on tumor cells in the context of solid tumor treated with checkpoint inhibitors targeting the PD …

[HTML][HTML] PD-L1 expression in advanced NSCLC: Insights into risk stratification and treatment selection from a systematic literature review

R Brody, Y Zhang, M Ballas, MK Siddiqui, P Gupta… - Lung cancer, 2017 - Elsevier
Tumors can evade immune detection by exploiting inhibitory immune checkpoints such as
the programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) pathway …

[HTML][HTML] Combined radiotherapy and anti–PD-L1 antibody synergistically enhances antitumor effect in non–small cell lung cancer

X Gong, X Li, T Jiang, H Xie, Z Zhu, F Zhou… - Journal of Thoracic …, 2017 - Elsevier
Introduction Immune escape frequently occurs and restricts the durability of the antitumor
immune response to radiotherapy. Programmed death 1 (PD-1) and programmed death …

PD-L1 expression in lung cancer and its correlation with driver mutations: a meta-analysis

M Zhang, G Li, Y Wang, Y Wang, S Zhao, P Haihong… - Scientific reports, 2017 - nature.com
Although many studies have addressed the prognostic value of programmed cell death-
ligand 1 (PD-L1) expression in lung cancer, the results remain controversial. A systematic …