Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …

Bones provide mechanical and protective function, while also serving as housing for marrow
and a site for regulation of calcium ion homeostasis. The properties of bones do not remain …

INTRODUCTION During aging, most organs in mammals become smaller (miniaturize) or
thinner, and their functions and regenerative capability also decline. Histologically, tissue …

Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

The study of human genetic disorders and mutant mouse models has provided evidence
that genome maintenance mechanisms, DNA damage signalling and metabolic regulation …

Aging is the outcome of a balance between damage and repair. The rate of aging and the
appearance of age-related pathology are modulated by stress response and repair …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

The aging of tissue-specific stem cell and progenitor cell compartments is believed to be
central to the decline of tissue and organ integrity and function in the elderly. Here, we …

Progressive DNA damage and mitochondrial decline are both considered to be prime
instigators of natural ageing. Traditionally, these two pathways have been viewed largely in …

Accumulation of DNA damage has been linked to the process of aging and to the onset of
age-related diseases including diabetes. Studies on progeroid syndromes have suggested …