Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

Heterochromatin is defined as a chromosomal domain harboring repressive H3K9me2/3 or
H3K27me3 histone modifications and relevant factors that physically compact the chromatin …

Transposable elements (TE) are repetitive genomic elements that harbor binding sites for
human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal …

Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …

Advancing the technologies for cellular reprogramming with high efficiency has significant
impact on regenerative therapy, disease modeling, and drug discovery. Biophysical cues …

In mammals, many retrotransposons are de-repressed during zygotic genome activation
(ZGA). However, their functions in early development remain elusive largely due to the …

How histone modifications regulate changes in gene expression during preimplantation
development in any species remains poorly understood. Using CUT&Tag to overcome …

Transposable elements (TEs), long discounted as 'selfish genomic elements,'are
increasingly appreciated as the drivers of genomic evolution, genome organization, and …

Background: DNA methylation (DNAme) and histone posttranslational modifications (PTMs)
play an integral role in the transcriptional regulation of specific sets of genes and …