The neurovascular unit–concept review

V Muoio, PB Persson, MM Sendeski - Acta physiologica, 2014 - Wiley Online Library
The cerebral hyperaemia is one of the fundamental mechanisms for the central nervous
system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in …

Vascular dysfunction in the pathogenesis of Alzheimer's disease—A review of endothelium-mediated mechanisms and ensuing vicious circles

LY Di Marco, A Venneri, E Farkas, PC Evans… - Neurobiology of …, 2015 - Elsevier
Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …

Inflammatory cytokines and Alzheimer's disease: a review from the perspective of genetic polymorphisms

F Su, F Bai, Z Zhang - Neuroscience bulletin, 2016 - Springer
Neuroinflammatory processes are a central feature of Alzheimer's disease (AD) in which
microglia are over-activated, resulting in the increased production of pro-inflammatory …

Blood–brain barrier dysfunction as a cause and consequence of Alzheimer's disease

MA Erickson, WA Banks - Journal of Cerebral Blood Flow & …, 2013 - journals.sagepub.com
The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …

Investigation of angiogenesis and its mechanism using zinc oxide nanoparticle-loaded electrospun tissue engineering scaffolds

R Augustine, EA Dominic, I Reju, B Kaimal… - Rsc Advances, 2014 - pubs.rsc.org
Angiogenesis through tissue engineering scaffolds is an important factor that determines the
success of a tissue engineering endeavor. Zinc oxide (ZnO) nanoparticles are well known …

Disruption in the blood‐brain barrier: The missing link between brain and body inflammation in bipolar disorder?

JP Patel, BN Frey - Neural plasticity, 2015 - Wiley Online Library
The blood‐brain barrier (BBB) regulates the transport of micro‐and macromolecules
between the peripheral blood and the central nervous system (CNS) in order to maintain …

Intracellular calcium dysregulation: implications for Alzheimer's disease

S Magi, P Castaldo, ML Macrì… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive
neuronal loss. AD is associated with aberrant processing of the amyloid precursor protein …

[HTML][HTML] Oxidative stress and the neurovascular unit

C Rinaldi, L Donato, S Alibrandi, C Scimone… - Life, 2021 - mdpi.com
The neurovascular unit (NVU) is a relatively recent concept that clearly describes the
relationship between brain cells and their blood vessels. The components of the NVU …

[HTML][HTML] A review and hypothesized model of the mechanisms that underpin the relationship between inflammation and cognition in the elderly

M Tangestani Fard, C Stough - Frontiers in aging neuroscience, 2019 - frontiersin.org
Age is associated with increased risk for several disorders including dementias,
cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with …

[HTML][HTML] The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease

YL Zhang, J Wang, ZN Zhang, Q Su… - Neural Regeneration …, 2022 - journals.lww.com
Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …