Circulating miRNA analysis for cancer diagnostics and therapy

L Valihrach, P Androvic, M Kubista - Molecular Aspects of Medicine, 2020 - Elsevier
Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

Considerations and suggestions for the reliable analysis of miRNA in plasma using qRT-PCR

E Ban, EJ Song - Genes, 2022 - mdpi.com
MicroRNAs (miRNAs) are promising molecules that can regulate gene expression, and their
expression level and type have been associated with early diagnosis, targeted therapy, and …

Serum NFL discriminates Parkinson disease from atypical parkinsonisms

TM Marques, A van Rumund, P Oeckl, HB Kuiperij… - Neurology, 2019 - AAN Enterprises
Objective To investigate the diagnostic value of serum neurofilament light chain (NFL) in
patients with clear signs of parkinsonism but whose specific diagnosis was yet uncertain …

Circulating exosome‐like vesicle and skeletal muscle microRNAs are altered with age and resistance training

D Xhuti, MI Nilsson, K Manta… - The Journal of …, 2023 - Wiley Online Library
The age‐related loss of skeletal muscle mass and functionality, known as sarcopenia, is a
critical risk factor for morbidity and all‐cause mortality. Resistance exercise training (RET) is …

Breast cancer-delivered exosomal miRNA as liquid biopsy biomarkers for metastasis prediction: a focus on translational research with clinical applicability

O Baldasici, V Pileczki, D Cruceriu, LI Gavrilas… - International Journal of …, 2022 - mdpi.com
Metastasis represents the most important cause of breast cancer-associated mortality. Even
for early diagnosed stages, the risk of metastasis is significantly high and predicts a grim …

Sedentary and trained older men have distinct circulating exosomal microRNA profiles at baseline and in response to acute exercise

VD Nair, Y Ge, S Li, H Pincas, N Jain… - Frontiers in …, 2020 - frontiersin.org
Exercise has multi-systemic benefits and attenuates the physiological impairments
associated with aging. Emerging evidence suggests that circulating exosomes mediate …

Challenges in using circulating micro-RNAs as biomarkers for cardiovascular diseases

K Felekkis, C Papaneophytou - International Journal of Molecular …, 2020 - mdpi.com
Micro-RNAs (miRNAs) play a pivotal role in the development and physiology of the
cardiovascular system while they have been associated with multiple cardiovascular …

A systematic way to infer the regulation relations of miRNAs on target genes and critical miRNAs in cancers

P Xu, Q Wu, J Yu, Y Rao, Z Kou, G Fang, X Shi… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are a class of important non-coding RNAs, which play important roles
in tumorigenesis and development by targeting oncogenes or tumor suppressor genes. One …

Development of circulating microRNA-based biomarkers for medical decision-making: a friendly reminder of what should NOT be done

P Lakkisto, LT Dalgaard, T Belmonte… - Critical Reviews in …, 2023 - Taylor & Francis
Circulating cell-free microRNAs (miRNAs) represent a major reservoir for biomarker
discovery. Unfortunately, their implementation in clinical practice is limited due to a profound …

Circulating MicroRNAs and extracellular vesicle-derived MicroRNAs as predictors of functional recovery in ischemic stroke patients: a systematic review and meta …

CC Burlacu, D Ciobanu, AV Badulescu… - International Journal of …, 2022 - mdpi.com
Stroke accounts for the second leading cause of death and a major cause of disability, with
limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers …