[HTML][HTML] Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
[HTML][HTML] Care gaps and recommendations in vestibular migraine: an expert panel summit
MP Mallampalli, HG Rizk, A Kheradmand… - Frontiers in …, 2022 - frontiersin.org
Vestibular migraine (VM) is an increasingly recognized pathology yet remains as an
underdiagnosed cause of vestibular disorders. While current diagnostic criteria are codified …
underdiagnosed cause of vestibular disorders. While current diagnostic criteria are codified …
[HTML][HTML] The effect of sex and estrus cycle stage on optogenetic spreading depression induced migraine-like pain phenotypes
AM Harriott, A Waruinge, V Appiah-Danquah… - The Journal of …, 2023 - Springer
Background Migraine is more prevalent in females, raising the possibility that sex and
gonadal hormones modulate migraine. We recently demonstrated that minimally invasive …
gonadal hormones modulate migraine. We recently demonstrated that minimally invasive …
[HTML][HTML] Levcromakalim provokes an acute rapid-onset migraine-like phenotype without inducing cortical spreading depolarization
Background Migraine headache attacks and accompanying sensory augmentation can be
induced by several agents including levcromakalim (LVC), that is also capable of provoking …
induced by several agents including levcromakalim (LVC), that is also capable of provoking …
Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs
SM Rahman, DW Buchholz, B Imbiakha… - Journal of …, 2024 - Am Soc Microbiol
ABSTRACT COVID-19 can cause neurological symptoms such as fever, dizziness, and
nausea. However, such neurological symptoms of SARS-CoV-2 infection have been hardly …
nausea. However, such neurological symptoms of SARS-CoV-2 infection have been hardly …
Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models
NP Nelson-Maney, L Balint… - The Journal of …, 2024 - Am Soc Clin Investig
Recently developed anti-migraine therapeutics targeting calcitonin gene-related peptide
(CGRP) signaling are effective, though their sites of activity remain elusive. Notably, the …
(CGRP) signaling are effective, though their sites of activity remain elusive. Notably, the …
[HTML][HTML] Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics
K Frimpong-Manson, YT Ortiz, LR McMahon… - Frontiers in Molecular …, 2024 - frontiersin.org
The individual and global burden of migraine is of such significance that there are
accelerated efforts to develop new therapies. New migraine therapeutics are needed to …
accelerated efforts to develop new therapies. New migraine therapeutics are needed to …
[HTML][HTML] CGRP administration into the cerebellum evokes light aversion, tactile hypersensitivity, and nociceptive squint in mice
M Wang, TL Duong, BJ Rea, JS Waite… - Frontiers in Pain …, 2022 - frontiersin.org
The neuropeptide calcitonin gene-related peptide (CGRP) is a major player in migraine
pathophysiology. Previous preclinical studies demonstrated that intracerebroventricular …
pathophysiology. Previous preclinical studies demonstrated that intracerebroventricular …
[HTML][HTML] Stimulation of CGRP-expressing neurons in the medial cerebellar nucleus induces light and touch sensitivity in mice
M Wang, WC Castonguay, TL Duong, MW Huebner… - Neurobiology of Pain, 2022 - Elsevier
Calcitonin gene-related peptide (CGRP) is considered a major player in migraine
pathophysiology. However, the location and mechanisms of CGRP actions in migraine are …
pathophysiology. However, the location and mechanisms of CGRP actions in migraine are …
Both systemic Calcitonin Gene Related Peptide (CGRP) and a vestibular challenge promote anxiety-related behaviors and dynamic imbalance in mice
Motion-induced anxiety and agoraphobia are more frequent symptoms in patients with
vestibular migraine than migraine without vertigo. The neuropeptide calcitonin gene-related …
vestibular migraine than migraine without vertigo. The neuropeptide calcitonin gene-related …