In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …

Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …

The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–
coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many …

Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their
mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of …

The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …

In the current chapter, we review approaches to the identification of the residues forming the
binding sites for agonists, antagonists, and allosteric modulators in the family of aminergic G …

Candidate olfactory receptors of the moth Heliothis virescens were found to be extremely
diverse from receptors of the fruitfly Drosophila melanogaster and the mosquito Anopheles …

Recent breakthroughs in the determination of the crystal structures of G protein-coupled
receptors (GPCRs) have provided new opportunities for structure-based drug design …

In this paper, we describe homology modeling of the alpha1A receptor based on the X-ray
structure of bovine rhodopsin. The protein model has been generated by applying ligand …