Calcium responses to various concentrations of histamine were monitored in Chinese
hamster ovary cells stably expressing the human histamine H1 receptor. The effects of …

Selective A 2B receptor antagonists and agonists may play a role in important pathologies
such as gastrointestinal, neurological (ie, Alzheimer disease and dementia) and …

Non‐nucleoside agonists of adenosine receptors were analysed at the A2A adenosine
receptor to simulate and compare their possible binding modes. The docking studies were …

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules.
These effects are mediated through a specific class of plasma membrane receptors called …

Three-dimensional models of the A1 and A2a adenosine receptors (AR) were constructed
by means of a homology procedure, using bovine rhodopsin as a template. In order to …

Extracellular adenosine mediates most of its physiological effects via an interaction with four
G protein-coupled receptors (GPCRs), the adenosine receptors (ARs). These ARs are …

Prostacyclin (PGI2) is one of the major vascular protectors against thrombosis and
vasoconstriction, caused by thromboxane A2. Understanding the molecular mechanisms of …

Residues in the second extracellular loop (e2) play a role in ligand binding in certain
aminergic G protein coupled receptors (GPCRs). N-[3-(1 H-Imidazol-4-yl) propyl)] …

Three-dimensional pharmacophore models of human adenosine receptor A 2A antagonists
were developed based on 23 diverse compounds selected from a large number of A 2A …

Residues of the second extracellular loop are believed to be important for ligand recognition
in adenosine receptors. Molecular modeling studies have suggested that one such residue …