Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …

The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …

Elucidating the design principles of regulatory networks driving cellular decision-making has
fundamental implications in mapping and eventually controlling cell-fate decisions. Despite …

Understanding the mechanisms that enable cancer cells to metastasize is essential in
preventing cancer progression. Here we examine the metabolic adaptations of metastasis …

Intra-tumor heterogeneity contributes to treatment failure and poor survival in urothelial
bladder carcinoma (UBC). Analyzing transcriptome from a UBC cohort, we report that intra …

Background Epithelial-mesenchymal plasticity (EMP) involves bidirectional transitions
between epithelial, mesenchymal and multiple intermediary hybrid epithelial/mesenchymal …

This study investigates the role of integrin β4 (ITGB4) and stemness-associated factor SOX2
in platinum resistance in lung squamous cell carcinoma (LUSC). The expression of SOX2 …

Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically
interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an …

Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are
indispensable guardians of the immune system and orchestrate the recognition and …

Inhibitory immune checkpoint (ICP) molecules are pivotal in inhibiting innate and acquired
antitumor immune responses, a mechanism frequently exploited by cancer cells to evade …